{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:43:01Z","timestamp":1785559381960,"version":"3.56.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I0BX002659"],"award-info":[{"award-number":["1I0BX002659"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>This study introduces a novel murine model of RPO using serial phenylephrine infusions to mimic chronic episodic hemodynamic stress. Unlike porcine models of RPO that demonstrate increased LV chamber stiffness and protection against strain-induced myocyte injury, mice exhibit reduced LV chamber stiffness and persistent myocyte apoptosis that is accompanied by loss systolic dysfunction with a preserved ejection fraction at rest. These findings indicate important species differences in the response to transient pressure overload.<\/jats:p>","DOI":"10.1152\/ajpheart.00892.2025","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:01:31Z","timestamp":1779390091000},"page":"H58-H66","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Brief repetitive pressure overload in mice induces eccentric remodeling and impaired contractile reserve"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6221-8625","authenticated-orcid":false,"given":"Jennifer K.","family":"Lang","sequence":"first","affiliation":[{"name":"Jacobs School of Medicine and Biomedical Sciences","place":["United States"]},{"name":"VA WNY Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pon","sequence":"additional","affiliation":[{"name":"Jacobs School of Medicine and Biomedical Sciences","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Eagler","sequence":"additional","affiliation":[{"name":"Jacobs School of Medicine and Biomedical Sciences","place":["United States"]},{"name":"VA WNY Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-6771","authenticated-orcid":false,"given":"Brian R.","family":"Weil","sequence":"additional","affiliation":[{"name":"Jacobs School of Medicine and Biomedical Sciences","place":["United States"]},{"name":"Jacobs School of Medicine and Biomedical Sciences","place":["United States"]},{"name":"VA WNY Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-6649","authenticated-orcid":false,"suffix":"Jr.","given":"John M.","family":"Canty","sequence":"additional","affiliation":[{"name":"Jacobs School of Medicine and Biomedical Sciences","place":["United States"]},{"name":"Jacobs School of Medicine and Biomedical Sciences","place":["United States"]},{"name":"VA WNY Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00036"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.966366"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.04.002"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2025.02.009"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2026.117795"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400828R"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.029"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.86.1.59"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/415198a"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.85.1.38"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.10.007"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000029803.93022.93"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00692-y"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.7.2694"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3791\/50983"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3791\/54818"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00697.2018"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-017-0731-4"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.05.065"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142243"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.06.015"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.323051"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/RES.0b013e3182582523"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072139"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2017.07.013"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170781"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.323659"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/circ.148.suppl_1.16888"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00441.2002"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/circ.152.suppl_3.4370247"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00892.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:59:37Z","timestamp":1781283577000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00892.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1152\/ajpheart.00892.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00892.2025","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2025-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}