{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:23:01Z","timestamp":1791523381177,"version":"4.3.4"},"reference-count":63,"publisher":"American Physiological Society","issue":"9","funder":[{"name":"Coordination for Improvement of Higher Education Personel (CAPES, Brasil)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:p>We investigated the effect of activating metabolically sensitive skeletal muscle afferents (muscle metaboreflex) on cerebral blood flow and the potentially confounding influence of concomitant changes in the partial pressure of arterial carbon dioxide. Eleven healthy males (25 \u00b1 4 yr) performed submaximal leg cycling exercise on a semirecumbent cycle ergometer (heart rate: \u223c120 beats\/min), and assessments were made of the partial pressure of end-tidal carbon dioxide (Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>), internal carotid artery blood flow (ICA<jats:sub>Q<\/jats:sub>) and conductance (ICA<jats:sub>CVC<\/jats:sub>), and middle cerebral artery mean blood velocity (MCAv<jats:sub>m<\/jats:sub>) and conductance index (MCA<jats:sub>CVCi<\/jats:sub>).The muscle metaboreflex was activated during cycling with leg blood flow restriction (BFR) or isolated with postexercise ischemia (PEI). In separate trials, Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>was either permitted to fluctuate spontaneously (control trial) or was clamped at 1 mmHg above resting levels (Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>clamp trial). In the control trial, leg cycling with BFR decreased Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>(\u0394\u22124.8 \u00b1 0.9 mmHg vs. leg cycling exercise) secondary to hyperventilation, while ICA<jats:sub>Q<\/jats:sub>, ICA<jats:sub>CVC<\/jats:sub>, and MCAv<jats:sub>m<\/jats:sub>were unchanged and MCA<jats:sub>CVCi<\/jats:sub>decreased. However, in the Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>clamp trial, leg cycling with BFR increased both MCAv<jats:sub>m<\/jats:sub>(\u03945.9 \u00b1 1.4 cm\/s) and ICA<jats:sub>Q<\/jats:sub>(\u039420.0 \u00b1 7.8 ml\/min) and attenuated the decrease in MCA<jats:sub>CVCi<\/jats:sub>, while ICA<jats:sub>CVC<\/jats:sub>was unchanged. In the control trial, PEI decreased Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>(\u0394\u22127.0 \u00b1 1.3 mmHg vs. rest), MCAv<jats:sub>m<\/jats:sub>and MCA<jats:sub>CVCi<\/jats:sub>, whereas ICA<jats:sub>Q<\/jats:sub>and ICA<jats:sub>CVC<\/jats:sub>were unchanged. In contrast, in the Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>clamp trial both ICA<jats:sub>Q<\/jats:sub>(\u039418.5 \u00b1 11.9 ml\/min) and MCAv<jats:sub>m<\/jats:sub>(\u03948.8 \u00b1 2.0 cm\/s) were elevated, while ICA<jats:sub>CVC<\/jats:sub>and MCA<jats:sub>CVCi<\/jats:sub>were unchanged. In conclusion, when hyperventilation-related decreases in Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>are prevented the activation of metabolically sensitive skeletal muscle afferent fibers increases cerebral blood flow.<\/jats:p>","DOI":"10.1152\/ajpheart.00894.2015","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T12:33:54Z","timestamp":1455366834000},"page":"H1201-H1209","source":"Crossref","is-referenced-by-count":28,"title":["Muscle metaboreflex and cerebral blood flow regulation in humans: implications for exercise with blood flow restriction"],"prefix":"10.1152","volume":"310","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-0409","authenticated-orcid":false,"given":"Eliza","family":"Prodel","sequence":"first","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom;"},{"name":"Department of Physiology and Pharmacology, Fluminense Federal University, Niter\u00f3i, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Balanos","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor D.","family":"Braz","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio C. L.","family":"Nobrega","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Fluminense Federal University, Niter\u00f3i, Brazil; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauro C.","family":"Vianna","sequence":"additional","affiliation":[{"name":"Faculty of Physical Education, University of Bras\u00edlia, Bras\u00edlia, Distrito Federal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7851-9222","authenticated-orcid":false,"given":"James P.","family":"Fisher","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016393"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.91008.2008"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1938.sp003592"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1937.sp003485"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00462.2010"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.163303"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00183.2010"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.10.018"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.04.157"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00624.2012"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.45.4.574"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.081687"},{"key":"B14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/JES.0b013e3182553430","volume":"40","author":"Davenport MH","year":"2012","journal-title":"Exerc Sport Sci Rev"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1042\/cs0600145"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.254722"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.185470"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140022"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.2.651"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.5.2120"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01266.2009"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00195.2007"},{"key":"B23","first-page":"213","volume":"48","author":"Gross PM","year":"1980","journal-title":"J Appl Physiol Respir Environ Exercise Physiol"},{"key":"B24","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1002\/cphy.c110065","volume":"2","author":"Haas TL","year":"2012","journal-title":"Compr Physiol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00636.2015"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00057-X"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.264.2.H553"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.5.1825"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1993.tb00333.x"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00474.2014"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101995"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-015-3253-2"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-2167-x"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.146290"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.10.021"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2013-0414"},{"key":"B37","first-page":"288","volume":"55","author":"McSwain SD","year":"2010","journal-title":"Respir Care"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)91053-7"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.071001"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.3.H1045"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1097\/jes.0b013e3180a031ec"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00573.2009"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0264-9"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70361-3"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00943.2011"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1997.00126.x"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200737090-00002"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.186767"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.68.4.1727"},{"key":"B50","first-page":"1358","volume":"52","author":"Robbins PA","year":"1982","journal-title":"J Appl Physiol Respir Environ Exercise Physiol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.099697"},{"key":"B52","first-page":"7","volume":"556","author":"Rowell LB","year":"1986","journal-title":"Acta Physiol Scand Suppl"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91539.2008"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0288-1"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00853.2007"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2014.09.014"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00208.2015"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.10.014"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00095.2015"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00211.2015"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-013-2733-5"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2012.01489.x"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu084"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00894.2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T02:25:23Z","timestamp":1654309523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00894.2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,1]]},"references-count":63,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,5,1]]}},"alternative-id":["10.1152\/ajpheart.00894.2015"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00894.2015","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,1]]}}}