{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:08:33Z","timestamp":1777090113341,"version":"3.51.4"},"reference-count":38,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p> Previous studies of reentrant arrhythmias in the heart have been performed in computer models and tissue experiments. We hypothesized that confluent monolayers of cardiac cells can provide a simple, controlled, and reproducible experimental model of reentry. Neonatal rat ventricular cells were cultured on 22-mm-diameter coverslips and stained with the voltage-sensitive dye RH-237. Recordings of transmembrane potentials were obtained from 61 sites with the use of a contact fluorescence imaging system. An electrical field stimulus, followed by a point stimulus, induced 39 episodes of sustained reentry and 21 episodes of nonsustained reentry. Sustained reentry consisted of single-loop ( n = 18 monolayers) or figure-of-eight ( n = 4) patterns. The cycle length, action potential duration at 80% repolarization, and conduction velocity were (in means \u00b1 SE) 358 \u00b1 33 ms, 118 \u00b1 12 ms, and 12.9 \u00b1 1.0 cm\/s for single loop and 311 \u00b1 78 ms, 137 \u00b1 18 ms, and 7.8 \u00b1 1.3 cm\/s for figure-of-eight, respectively. Electrical termination by 6- to 13-V\/cm field pulses or 15- to 20-V point stimuli was successful in 60% of the attempts. In summary, highly stable reentry can be induced, sustained for extensive periods of time, and electrically terminated in monolayers of cultured neonatal rat cardiac myocytes. <\/jats:p>","DOI":"10.1152\/ajpheart.00896.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:10:42Z","timestamp":1425413442000},"page":"H449-H456","source":"Crossref","is-referenced-by-count":47,"title":["Functional reentry in cultured monolayers of neonatal rat cardiac  cells"],"prefix":"10.1152","volume":"285","author":[{"given":"Shahriar","family":"Iravanian","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, The Johns Hopkins University,  Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelena","family":"Nabutovsky","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Johns Hopkins University,  Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae-Ryon","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Johns Hopkins University,  Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumita","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Johns Hopkins University,  Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nenad","family":"Bursac","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Johns Hopkins University,  Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Johns Hopkins University,  Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.33.1.54"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.39.2.168"},{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.1.9"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.2.852"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1991.tb02794.x"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.10283"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.2.H433"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000047530.88338.EB"},{"key":"REF9","unstructured":"Davidenko JM. 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