{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:15:52Z","timestamp":1791591352293,"version":"4.3.4"},"reference-count":29,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100009708","name":"Appalachian State University","doi-asserted-by":"crossref","award":["COVID-19 Cluster Award"],"award-info":[{"award-number":["COVID-19 Cluster Award"]}],"id":[{"id":"10.13039\/100009708","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:p> This study was the first to investigate the vascular implications of contracting SARS-CoV-2 among young, otherwise healthy adults. Using a cross-sectional design, this study assessed vascular function 3\u20134\u2009wk after young adults tested positive for SARS-CoV-2. The main findings from this study were a strikingly lower vascular function and a higher arterial stiffness compared with healthy controls. Together, these results suggest rampant vascular effects seen weeks after contracting SARS-CoV-2 in young adults. <\/jats:p>","DOI":"10.1152\/ajpheart.00897.2020","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T17:41:46Z","timestamp":1607708506000},"page":"H404-H410","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":159,"title":["Vascular alterations among young adults with SARS-CoV-2"],"prefix":"10.1152","volume":"320","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6300-7600","authenticated-orcid":false,"given":"Stephen M.","family":"Ratchford","sequence":"first","affiliation":[{"name":"Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon L.","family":"Stickford","sequence":"additional","affiliation":[{"name":"Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-7693","authenticated-orcid":false,"given":"Valesha M.","family":"Province","sequence":"additional","affiliation":[{"name":"Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8213-638X","authenticated-orcid":false,"given":"Nina","family":"Stute","sequence":"additional","affiliation":[{"name":"Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-8799","authenticated-orcid":false,"given":"Marc A.","family":"Augenreich","sequence":"additional","affiliation":[{"name":"Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel K.","family":"Koontz","sequence":"additional","affiliation":[{"name":"Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landry K.","family":"Bobo","sequence":"additional","affiliation":[{"name":"Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail S.L.","family":"Stickford","sequence":"additional","affiliation":[{"name":"Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.510461"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.004"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0629-x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.05.003"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12895"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046941"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30937-5"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243246"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00253"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2009787"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28946"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa230"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.150821"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.147322"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00557.2017"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl254"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1067\/mva.1990.19707"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.9.960"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93147-F"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.12881"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.864801"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-010-9616-1"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.5.1314"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.4.1807"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301675"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2020.10.005"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.224741"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.061"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00897.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T09:00:56Z","timestamp":1624438856000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.00897.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,1]]}},"alternative-id":["10.1152\/ajpheart.00897.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00897.2020","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]},"assertion":[{"value":"2020-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}