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Our previous studies have demonstrated that overexpression of angiotensin-converting enzyme 2 (ACE2) prevents cardiac remodeling and hypertrophy during chronic infusion of angiotensin II (ANG II). This, coupled with the knowledge that ACE2 is a key enzyme in the formation of ANG-(1\u20137), led us to hypothesize that chronic infusion of ANG-(1\u20137) would prevent cardiac remodeling induced by chronic infusion of ANG II. Infusion of ANG II into adult Sprague-Dawley rats resulted in significantly increased blood pressure, myocyte hypertrophy, and midmyocardial interstitial fibrosis. Coinfusion of ANG-(1\u20137) resulted in significant attenuations of myocyte hypertrophy and interstitial fibrosis, without significant effects on blood pressure. In a subgroup of animals also administered [d-Ala<jats:sup>7<\/jats:sup>]-ANG-(1\u20137) (A779), an antagonist to the reported receptor for ANG-(1\u20137), there was a tendency to attenuate the antiremodeling effects of ANG-(1\u20137). Chronic infusion of ANG II, with or without coinfusion of ANG-(1\u20137), had no effect on ANG II type 1 or type 2 receptor binding in cardiac tissue. Together, these findings indicate an antiremodeling role for ANG-(1\u20137) in cardiac tissue, which is not mediated through modulation of blood pressure or altered cardiac angiotensin receptor populations and may be at least partially mediated through an ANG-(1\u20137) receptor. <\/jats:p>","DOI":"10.1152\/ajpheart.00937.2006","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T20:38:32Z","timestamp":1163450312000},"page":"H736-H742","source":"Crossref","is-referenced-by-count":294,"title":["Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1\u20137)"],"prefix":"10.1152","volume":"292","author":[{"given":"Justin L.","family":"Grobe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Mecca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lingis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya A.","family":"Bolton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juline M.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Speth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan K.","family":"Raizada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Katovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000092888.63239.54"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1007\/s001090100210"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00632.2005"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8651(05)70154-5"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi114"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000175813.04375.8a"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200302000-00017"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.3317\/jraas.2003.028"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1038\/nature00786"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(94)00062-8"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000205761.22353.5f"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1383"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00312.2005"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.1.1"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(03)00177-9"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410080011002"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00170.2004"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1081\/IMM-55807"},{"key":"R19","unstructured":"Ferrario CM. 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