{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:05Z","timestamp":1792788305607,"version":"4.5.0"},"reference-count":26,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:p>Increased cardiac output in pregnancy is associated with cardiac remodeling and possible reduction in contractility, which may worsen in preeclampsia. Left ventricular (LV) geometry and function were compared between nonpregnant controls ( n = 12) and normotensive ( n = 44) and preeclamptic ( n = 15) pregnant women using echocardiography. Load-independent comparisons of LV systolic function compared end-systolic stress (ESS) and rate-corrected velocity of circumferential fiber shortening ( V<jats:sub>CFC<\/jats:sub>). Mean arterial pressures were 101 \u00b1 14 mmHg in preeclampsia, 76 \u00b1 6 mmHg in normotensive pregnancy, and 78 \u00b1 6 mmHg in controls ( P &lt; 0.005 vs. preeclampsia). LV mass increased during normotensive pregnancy (66 \u00b1 13 to 76 \u00b1 16 g\/m<jats:sup>2<\/jats:sup>; P &lt; 0.05; controls, 65 \u00b1 10 g\/m<jats:sup>2<\/jats:sup>; P &lt; 0.05) and was greater in preeclampsia (90 \u00b1 18 g\/m<jats:sup>2<\/jats:sup>; P &lt; 0.05). In normotensive pregnancy, ESS decreased (59 \u00b1 9 to 52 \u00b1 11 g\/cm<jats:sup>2<\/jats:sup>; P &lt; 0.05; controls, 66 \u00b1 14 g\/cm<jats:sup>2<\/jats:sup>; P &lt; 0.005). ESS was greater in preeclampsia (60 \u00b1 14 g\/cm<jats:sup>2<\/jats:sup>; P &lt; 0.05). In controls, there was an inverse relationship between ESS and V<jats:sub>CFC<\/jats:sub>( r = \u22120.78). The ESS- V<jats:sub>CFC<\/jats:sub>relationships in normotensive and preeclamptic pregnancy were unchanged from controls. We conclude that LV hypertrophy in normotensive and preeclamptic pregnancy matches changes in cardiac work, and LV contractility is preserved.<\/jats:p>","DOI":"10.1152\/ajpheart.00966.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:04:03Z","timestamp":1425413043000},"page":"H1627-H1633","source":"Crossref","is-referenced-by-count":197,"title":["Structural and functional changes in left ventricle during normotensive and preeclamptic pregnancy"],"prefix":"10.1152","volume":"283","author":[{"given":"Lisa A.","family":"Simmons","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Sydney, Sydney, New South Wales 2006; and Departments of"},{"name":"Cardiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian G.","family":"Gillin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Sydney, Sydney, New South Wales 2006; and Departments of"},{"name":"Renal Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richmond W.","family":"Jeremy","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Sydney, Sydney, New South Wales 2006; and Departments of"},{"name":"Cardiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.5694\/j.1326-5377.1993.tb121919.x","volume":"158","author":"Australasian Society for the Study of Hypertension in Pregnancy","year":"1993","journal-title":"Med J Aust"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.1996.tb00881.x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.7.1827"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00738-8"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80397-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1159\/000293604"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.4.613"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90358-9"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960110511"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80463-1"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70247-3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.2.160"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.3.434"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)90820-7"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)90024-C"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a062051"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70297-7"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.4.511"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.4.667"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00151-0"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540030045030"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.256.4.H1060"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.6.1909"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(77)90068-6"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90483-7"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)90418-6"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.00966.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T13:25:33Z","timestamp":1598793933000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.00966.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,1]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10,1]]}},"alternative-id":["10.1152\/ajpheart.00966.2001"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.00966.2001","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10,1]]}}}