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Twelve-month treatment with GLP-1RA, SGLT-2i, and their combination confers significant reductions in cIMT and A\u03b21\u201340 compared with insulin. cIMT regression was associated with A\u03b21\u201340 and malondialdehyde reductions. Our findings support that newer antidiabetic agents can favorably modify structural and biochemical markers of atherosclerosis.<\/jats:p>","DOI":"10.1152\/ajpheart.00996.2025","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:00:14Z","timestamp":1769274014000},"page":"H610-H619","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["GLP-1 receptor agonists, SGLT-2 inhibitors, and their combination: effects on carotid atherosclerosis regression, oxidative stress, and amyloid-\u03b21\u201340 in diabetes"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-7886","authenticated-orcid":false,"given":"Ignatios","family":"Ikonomidis","sequence":"first","affiliation":[{"name":"National and Kapodistrian University of 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