{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:46:03Z","timestamp":1792655163146,"version":"4.5.0"},"reference-count":129,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100009633","name":"HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD037831"],"award-info":[{"award-number":["R01HD037831"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"HHS | NIH | NIH Office of the Director","doi-asserted-by":"publisher","award":["S10OD023438"],"award-info":[{"award-number":["S10OD023438"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL149762"],"award-info":[{"award-number":["R01HL149762"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K99HL151889"],"award-info":[{"award-number":["K99HL151889"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL091905"],"award-info":[{"award-number":["R01HL091905"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL137852"],"award-info":[{"award-number":["R01HL137852"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL139585"],"award-info":[{"award-number":["R01HL139585"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL146054"],"award-info":[{"award-number":["R01HL146054"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL146562"],"award-info":[{"award-number":["R01HL146562"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL135901"],"award-info":[{"award-number":["R01HL135901"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL088554"],"award-info":[{"award-number":["R01HL088554"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL137112"],"award-info":[{"award-number":["R01HL137112"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL123301"],"award-info":[{"award-number":["R01HL123301"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL121871"],"award-info":[{"award-number":["R01HL121871"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL088105"],"award-info":[{"award-number":["R01HL088105"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL142808"],"award-info":[{"award-number":["R01HL142808"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL146914"],"award-info":[{"award-number":["R01HL146914"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R00HL116769"],"award-info":[{"award-number":["R00HL116769"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL151413"],"award-info":[{"award-number":["R01HL151413"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01HL134604"],"award-info":[{"award-number":["P01HL134604"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"HHS | NIH | National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R21EB026518"],"award-info":[{"award-number":["R21EB026518"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK076169"],"award-info":[{"award-number":["DK076169"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK115255"],"award-info":[{"award-number":["DK115255"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES014639"],"award-info":[{"award-number":["R01ES014639"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R00GM118885"],"award-info":[{"award-number":["R00GM118885"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM130459"],"award-info":[{"award-number":["P20GM130459"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RF1NS110044"],"award-info":[{"award-number":["RF1NS110044"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R61NS115132"],"award-info":[{"award-number":["R61NS115132"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS082521"],"award-info":[{"award-number":["R01NS082521"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:p>The measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the normal and diseased cardiovascular system and has provided a molecular understanding of the cells that constitutes arteries and veins and their interaction. Further, this approach has allowed the discovery of vital pharmacological treatments for cardiovascular diseases. However, the expansion of the vascular physiology field has also brought new concerns over scientific rigor and reproducibility. Therefore, it is appropriate to set guidelines for the best practices of evaluating vascular function in isolated vessels. These guidelines are a comprehensive document detailing the best practices and pitfalls for the assessment of function in large and small arteries and veins. Herein, we bring together experts in the field of vascular physiology with the purpose of developing guidelines for evaluating ex vivo vascular function. By using this document, vascular physiologists will have consistency among methodological approaches, producing more reliable and reproducible results.<\/jats:p>","DOI":"10.1152\/ajpheart.01021.2020","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T12:23:42Z","timestamp":1620995022000},"page":"H77-H111","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":192,"title":["Guidelines for the measurement of vascular function and structure in isolated arteries and veins"],"prefix":"10.1152","volume":"321","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-3568","authenticated-orcid":true,"given":"Camilla F.","family":"Wenceslau","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-779X","authenticated-orcid":true,"given":"Cameron G.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Earley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Molecular and Cellular         Signaling in the Cardiovascular System, Reno School of Medicine, University of Nevada, Reno, Nevada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"England","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Filosa","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-8256","authenticated-orcid":true,"given":"Styliani","family":"Goulopoulou","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-7867","authenticated-orcid":true,"given":"David D.","family":"Gutterman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical College of Wisconsin Cardiovascular Center, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-6294","authenticated-orcid":true,"given":"Brant E.","family":"Isakson","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9028-4021","authenticated-orcid":true,"given":"Nancy L.","family":"Kanagy","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Martinez-Lemus","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapnil K.","family":"Sonkusare","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratish","family":"Thakore","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Molecular and Cellular         Signaling in the Cardiovascular System, Reno School of Medicine, University of Nevada, Reno, Nevada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-0659","authenticated-orcid":true,"given":"Aaron J.","family":"Trask","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Research, The Heart Center,         The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9653-6357","authenticated-orcid":true,"given":"Stephanie W.","family":"Watts","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Clinton","family":"Webb","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Research Center, Department of Cell Biology and Anatomy, University of South Carolina, Columbia, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04312.x"},{"key":"B2","first-page":"4: 274","volume":"71","author":"Lubitz SA","year":"2004","journal-title":"Mt Sinai J Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgx085"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1902.sp000911"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00087.2018"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.07.008"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/24388"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313926"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.3.341"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.266.3.H952"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000827"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00854.2009"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb13114.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.268.2.H670"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aal3806"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310038"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211946109"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.2.387"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/s0008-6363(98)00020-0"},{"key":"B20","first-page":"59","volume":"211","author":"Turlapaty PD","year":"1979","journal-title":"J Pharmacol Exp Ther"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1980.tb07892.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0161-4630(80)90099-3"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2147\/IBPC.S59535"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.37.2.313"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110151"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s12565-009-0047-9"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00125.2002"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.228999"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12371"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c160016"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00634.2020"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2012.00172.x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114435"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00033.2008"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2004.028811"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.222778"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4486-14.2015"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1300-16.2016"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3674-14.2015"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/srep05309"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3791\/53825"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.75.3.0433"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/nature07525"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fnene.2011.00009"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110533108"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-020-00305-x"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706495"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.31"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1780-15.2015"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15616138"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1159\/000100991"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.119990"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5099"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1242\/dev.135962"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2970-1"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3109\/10641969109042063"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190577"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13734"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.05.028"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311720"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1042\/CS20201099"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1113\/JP277643"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105273"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016929"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314731"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029972"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00491.2020"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1113\/JP274831"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13126"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305500"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001238"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00037"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0024com"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00341"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000220381.40739.dd"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00656.2003"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58368-x"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.09.008"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2012.10.006"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.01.015"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1152\/advances.2003.27.4.201"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.245746"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/260617a0"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1980.tb10977.x"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932631"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932043"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2014.11.001"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.258.1.H127"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1113\/JP272834"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00923.2003"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2011.00131.x"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.12965\/jer.2040432.216"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1159\/000112513"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1969.216.6.1343"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00314-X"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00118.2003"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00634.2002"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00088.2019"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.269.5.H1590"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00323.2005"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124705"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2001.tb00157.x"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.267.1.H326"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1986.250.6.H1145"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.931672"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1981.241.1.H108"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.256.2.H383"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01006.2006"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00099"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01463"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15203"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07954"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-015-1333-4"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00110.2017"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3791\/57451"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00557.2013"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0201-0"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00542.2019"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt034"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00604.2012"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0750-8"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155377"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.119726"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.70402"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg087"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200417150121"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.8.4.344"},{"key":"B128","volume-title":"Fitting Models to Biological Data Using Linear and Nonlinear Regression: A Practical Guide to Curve Fitting","author":"Motulsky H","year":"2003"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1113\/JP280389"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.01021.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T16:10:04Z","timestamp":1624637404000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.01021.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":129,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7,1]]}},"alternative-id":["10.1152\/ajpheart.01021.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.01021.2020","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]},"assertion":[{"value":"2020-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}