{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:54:18Z","timestamp":1790988858282,"version":"4.1.0"},"reference-count":37,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p> In experimental animal and cell culture models, activation of peroxisome proliferator-activated receptor (PPAR) \u03b3 in heart has been shown to have beneficial effects on cardiac function and cardiomyocyte physiology. The goal of this study was to identify the signaling pathway by which PPAR\u03b3 activation protects cardiomyocytes from the deleterious effects of hypertrophic stimuli. In primary cardiomyocyte cultures, we found that genetic or pharmacological activation of PPAR\u03b3 protected cells from cardiac hypertrophy induced by \u03b1-adrenergic stimulation. Examination of gene expression in these cells revealed a surprising increase in the expression of adiponectin in cardiomyocytes and secretion of the high-molecular-weight form of the hormone into media. Using RNAi to block PPAR\u03b3-induced adiponectin production or adiponectin receptor gene expression, we found that the PPAR\u03b3-mediated anti-hypertrophic effect required cardiomyocyte-produced adiponectin, as well as an intact adiponectin signaling pathway. Furthermore, mice expressing constitutive-active PPAR\u03b3 and cardiomyocyte specific adiponectin expression were protected from high-fat diet-induced cardiac hypertrophy and remodeling. These findings demonstrate that functional adiponectin hormone can be produced from the heart and raise the possibility that beneficial effects of PPAR\u03b3 activation in heart could be due in part to local production of adiponectin that acts on cardiomyocytes in an autocrine manner. <\/jats:p>","DOI":"10.1152\/ajpheart.01032.2009","type":"journal-article","created":{"date-parts":[[2010,7,12]],"date-time":"2010-07-12T06:20:32Z","timestamp":1278915632000},"page":"H690-H698","source":"Crossref","is-referenced-by-count":39,"title":["Endogenously produced adiponectin protects cardiomyocytes from hypertrophy by a PPAR\u03b3-dependent autocrine mechanism"],"prefix":"10.1152","volume":"299","author":[{"given":"Rajesh H.","family":"Amin","sequence":"first","affiliation":[{"name":"Department of Pathology, Center for Integrative Metabolic &amp; Endocrine Research, Wayne State University School of Medicine, Detroit, Michigan; and"},{"name":"Department of Pharmacal Sciences and Boshell Diabetes and Metabolic Research Program, Auburn University, Auburn, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh T.","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Pathology, Center for Integrative Metabolic &amp; 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