{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:15:58Z","timestamp":1768889758316,"version":"3.49.0"},"reference-count":34,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p>Human studies suggest that cardiovascular neural sympathetic control is predominantly modulated by the right cerebral hemisphere. It is unknown whether post-ganglionic sympathetic activity [muscle sympathetic nerve activity (MSNA)] shows any functional asymmetry. Eight right-handed volunteers (3 women and 5 men, 32 \u00b1 2 yr of age) underwent ECG, beat-by-beat blood pressure, respiratory activity, and simultaneous right and left MSNA recordings during spontaneous and controlled breathing (CB, 15 breaths\/min, 0.25 Hz). Dynamic carotid baroreceptor stimulation was obtained by 0.1-Hz sinusoidal suction, from 0 to \u221250 mmHg, randomly applied to the right, left, and combined right and left sides of the neck during CB. Laterality was assessed by changes in the MSNA burst rate (in bursts\/min, and bursts\/100 beats), strength [amplitude (A) and area (AA)], and the oscillatory component at 0.1 Hz during baroreceptor stimulation. Amplitude parameters were normalized by CB burst mean amplitude and area of the same side. At rest, the right and left MSNA burst rate and total MSNA activity were similar. Conversely, the right MSNA normalized burst A<jats:sub>N<\/jats:sub>(1.36 \u00b1 0.18) and AA<jats:sub>N<\/jats:sub>(1.31 \u00b1 0.16) were larger than the left MSNA A<jats:sub>N<\/jats:sub>(1.04 \u00b1 0.09) and AA<jats:sub>N<\/jats:sub>(1.02 \u00b1 0.08). Unilateral and bilateral carotid baroreflex stimulation abolished the right prevalence of A<jats:sub>N<\/jats:sub>and AA<jats:sub>N<\/jats:sub>. In conclusion, the right lateralization of sympathetic activity to the vessels is indicated by normalized burst strength parameters of bilateral MSNA recordings at rest during spontaneous breathing. Carotid baroreceptor stimulation disrupted such expression of MSNA lateralization possibly by disturbing the synchronizing action of right cerebral hemisphere.<\/jats:p>","DOI":"10.1152\/ajpheart.01045.2008","type":"journal-article","created":{"date-parts":[[2009,4,11]],"date-time":"2009-04-11T00:44:50Z","timestamp":1239410690000},"page":"H1758-H1765","source":"Crossref","is-referenced-by-count":40,"title":["Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation"],"prefix":"10.1152","volume":"296","author":[{"given":"Andr\u00e9","family":"Diedrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Porta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Barbic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Brychta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Bonizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Diedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Cerutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaello","family":"Furlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62272-1"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000038905.75660.BD"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000138452.81003.4c"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000173400.19346.bd"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1972.tb05157.x"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Eckberg DL.The human respiratory gate.J Physiol548: 339\u2013352, 2003.","DOI":"10.1113\/jphysiol.2003.037192"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013338"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015766"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Eckberg DL, Sleight P.Human Baroreflexes in Health and Disease.Oxford: Oxford University Press, 1992.","DOI":"10.1093\/oso\/9780198576938.001.0001"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2006.02.004"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000084540.91605.0C"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.8.886"},{"key":"R13","unstructured":"Galigekere RR, Shoemaker JK.Interpreting power-spectral measures extracted from sympathetic nerve activity: possibilities and pitfalls.Computers in Cardiology31: 465\u2013468, 2004."},{"key":"R14","unstructured":"Gootman PM, Cohen MI.The interrelationships between sympathetic discharge and central respiratory drive. In:Central Rhythmic and Regulation, edited by Umbach W and Koepchen HP. Stuttgard: Hippokrates Verlag, 1974."},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.3.1199"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Henry JL, Calaresu FR.Excitatory and inhibitory inputs from medullary nuclei projecting to spinal cardioacceleratory neurons in the cat.Exp Brain Res20: 485\u2013504, 1974.","DOI":"10.1007\/BF00238015"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1006"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Kimmerly DS, O'Leary DD, Menon SR, Gati SJ, Shoemaker JK.Cortical regions associated with autonomic cardiovascular regulation during lower body negative pressure in humans.J Physiol331\u2013345, 2005.","DOI":"10.1113\/jphysiol.2005.091637"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200402090-00029"},{"key":"R20","unstructured":"Mosqueda-Garcia R.Microneurography in neurological research.Am Acad Neurol2: 4\u20135, 1996."},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1006"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Oppenheimer SM, Gelb A, Girvin JP, Hachinski VC.Cardiovascular effects of human insular cortex stimulation.Neurology1727\u20131732, 1992.","DOI":"10.1212\/WNL.42.9.1727"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.59.2.178"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.6.1441"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2000.00764.x"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.3.H1040"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp012050"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1007\/BF02267819"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.17.2076"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.07.076"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1982.242.2.H185"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020025"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550180055012"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.9.1408"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.01045.2008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T15:21:26Z","timestamp":1710256886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.01045.2008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1152\/ajpheart.01045.2008"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.01045.2008","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}