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In monolayers of neonatal rat cardiomyocytes in which rotating waves of activity were initiated by premature stimuli, we used the Ca<jats:sup>2+<\/jats:sup>-sensitive indicator fluo 4 to observe propagating wave patterns. The interaction of the spiral tip with a paced wave was then monitored at a high spatial resolution. In the course of the experiments, we observed spiral wave pinning to local heterogeneities within the myocyte layer. High-frequency pacing led, in a majority of cases, to successful termination of spiral activity. Our data show that 1) stable spiral waves in cardiac monolayers tend to be pinned to local heterogeneities or areas of altered conduction, 2) overdrive pacing can shift a rotating wave from its original site, and 3) the wave break, formed as a result of interaction between the spiral tip and a paced wave front, moves by a paced-induced drift mechanism to an area where it may become unstable or collide with a boundary. The data were complemented by numerical simulations, which was used to further analyze experimentally observed behavior. <\/jats:p>","DOI":"10.1152\/ajpheart.01060.2006","type":"journal-article","created":{"date-parts":[[2007,3,24]],"date-time":"2007-03-24T00:37:45Z","timestamp":1174696665000},"page":"H503-H513","source":"Crossref","is-referenced-by-count":74,"title":["Interaction between spiral and paced waves in cardiac tissue"],"prefix":"10.1152","volume":"293","author":[{"given":"Konstantin","family":"Agladze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Krinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narine","family":"Sarvazyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1021\/jp002237n"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/296424a0"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.33.1.54"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.4.H1905"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00096.2002"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00381.2003"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011853"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400984101"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.09.014"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00579.x"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1142\/S0218127491000336"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.6.1166"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4809(87)90048-6"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000130529.18016.35"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2000.tb00029.x"},{"key":"R16","unstructured":"Ermakova EA, Krinsky VI, Panfilov AV, Pertsov AM. 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