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Respiration, heart rate, and blood pressure were monitored in eight normal subjects and nine untreated OSAS patients in relaxed wakefulness and stage 2 and rapid eye movement sleep. A computer-controlled ventilator delivered inspiratory pressures that varied randomly from breath to breath. Application of the model to the corresponding subject responses allowed the delineation of the three components of HRV. In all states, RCC gain was lower in OSAS patients than in normal subjects ( P &lt; 0.04). ABR gain was also reduced in OSAS patients ( P &lt; 0.03). RCC and ABR gains increased from wakefulness to sleep ( P &lt; 0.04). However, there was no difference in PSR gain between subject groups or across states. The findings of this study suggest that the adverse autonomic effects of OSAS include impairment of baroreflex gain and central respiratory-cardiovascular coupling, but the component of respiratory sinus arrhythmia that is mediated by lung vagal feedback remains intact. <\/jats:p>","DOI":"10.1152\/ajpheart.01065.2003","type":"journal-article","created":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:24:14Z","timestamp":1097195054000},"page":"H1103-H1112","source":"Crossref","is-referenced-by-count":51,"title":["Determinants of heart rate variability in obstructive sleep apnea syndrome during wakefulness and sleep"],"prefix":"10.1152","volume":"288","author":[{"given":"J. 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