{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:41:38Z","timestamp":1790401298566,"version":"4.1.0"},"reference-count":43,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"The work herein represents a novel approach for the modeling of low-density lipoprotein (LDL) transport from the artery lumen into the arterial wall, taking into account the effects of local wall shear stress (WSS) on the endothelial cell layer and its pathways of volume and solute flux. We have simulated LDL transport in an axisymmetric representation of a stenosed coronary artery, where the endothelium is represented by a three-pore model that takes into account the contributions of the vesicular pathway, normal junctions, and leaky junctions also employing the local WSS to yield the overall volume and solute flux. The fraction of leaky junctions is calculated as a function of the local WSS based on published experimental data and is used in conjunction with the pore theory to determine the transport properties of this pathway. We have found elevated levels of solute flux at low shear stress regions because of the presence of a larger number of leaky junctions compared with high shear stress regions. Accordingly, we were able to observe high LDL concentrations in the arterial wall in these low shear stress regions despite increased filtration velocity, indicating that the increase in filtration velocity is not sufficient for the convective removal of LDL.<\/jats:p>","DOI":"10.1152\/ajpheart.01082.2007","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T20:54:56Z","timestamp":1197665696000},"page":"H909-H919","source":"Crossref","is-referenced-by-count":126,"title":["Computational modeling of coupled blood-wall mass transport of LDL: effects of local wall shear stress"],"prefix":"10.1152","volume":"294","author":[{"given":"Ufuk","family":"Olgac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vartan","family":"Kurtcuoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimos","family":"Poulikakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheatmasstransfer.2005.10.041"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01188.2006"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(03)00053-1"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1115\/1.2834303"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(74)90097-1"},{"key":"R6","unstructured":"Curry FE\n .\n Mechanics and thermodynamics of transcapillary exchange. In:\n Handbook of Physiology, The Cardiovascular System, Microcirculation,\n Bethesda, MD: Am Physiol Soc, 1984, sect. 2, vol. IV, part 1, p. 309\u2013374."},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.1.232"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.46.070177.004341"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Gradus-Pizlo I\n , Bigelow B, Mahomed Y, Sawada SG, Rieger K, Feigenbaum H.\n Left anterior descending coronary artery wall thickness measured by high-frequency transthoracic and epicardial echocardiography includes adventitia.\n Am J Cardiol\n 91\n : 27\u201332, 2003.","DOI":"10.1016\/S0002-9149(02)02993-4"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1115\/1.2895794"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.1.61"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Imberti B\n , Seliktar D, Nerem RM, Remuzzi A.\n The response of endothelial cells to fluid shear stress using a co-culture model of the arterial wall.\n Endothelium New York\n 9\n : 11\u201323, 2002.","DOI":"10.1080\/10623320210714"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1114\/1.1349704"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(99)00226-2"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1080\/10255840108908022"},{"key":"R16","unstructured":"Leveque MA\n .\n Le problem de phechange de chaleur a l'interieur d'un tube cylindrique.\n Ann Mines\n 13\n : 256\u2013299, 1928."},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.6.2.220"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.10.5.703"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.9.2.230"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1038\/35025203"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.3.532"},{"key":"R22","unstructured":"Milnor WR\n .\n Hemodynamics\n . Baltimore, MD. Williams & Wilkins, 1989."},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1114\/1.1467924"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.1.74"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.04.024"},{"key":"R26","unstructured":"Ross R\n .\n Atherosclerosis: a defense-mechanism gone.\n Am J Pathol\n 143\n : 987\u20131002, 1993."},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1299\/jsmec.47.992"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.268.2.H535"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.5.912"},{"key":"R30","unstructured":"Snelting-Havinga I\n , Mommaas M, Van Hinsbergh VW, Daha MR, Daems WT, Vermeer BJ.\n Immunoelectron microscopic visualization of the transcytosis of low density lipoproteins in perfused rat arteries.\n Eur J Cell Biol\n 48\n : 27\u201336, 1989."},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1115\/1.1427041"},{"key":"R32","unstructured":"Suciu A\n .\n Effects of External Forces on Endothelial Cells\n (PhD thesis). EPFL, Switzerland, 1997."},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01281.2006"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-006-9144-2"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.5.040202.121529"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1984.247.5.H784"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.257.2.H452"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.71.4.883"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1979.236.1.H53"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1007\/BF02345458"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041590112"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.248.6.H945"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1115\/1.2894890"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.01082.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:08:32Z","timestamp":1567958912000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.01082.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1152\/ajpheart.01082.2007"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.01082.2007","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}