{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:42:33Z","timestamp":1789951353005,"version":"4.0.1"},"reference-count":45,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>\n                    Several animal models of atrial fibrillation (AF) have been developed that demonstrate either atrial structural remodeling or atrial electrical remodeling, but the characteristics and spatiotemporal organization of the AF between the models have not been compared. Thirty-nine dogs were divided into five groups: rapid atrial pacing (RAP), chronic mitral regurgitation (MR), congestive heart failure (CHF), methylcholine (Meth), and control. Right and left atria (RA and LA, respectively) were simultaneously mapped during episodes of AF in each animal using high-density (240 electrodes) epicardial arrays. Multiple 30-s AF epochs were recorded in each dog. Fast Fourier transform was calculated every 1 s over a sliding 2-s window, and dominant frequency (DF) was determined. Stable, discrete, high-frequency areas were seen in none of the RAP or control dogs, four of nine MR dogs, four of six CHF dogs, and seven of nine Meth dogs in either the RA or LA or both. Average DFs in the Meth model were significantly greater than in all other models in both LA and RA except LA DFs in the RAP model. The RAP model was the only one with a consistent LA-to-RA DF gradient (9.5 \u00b1 0.2 vs. 8.3 \u00b1 0.3 Hz, P &lt; 0.00005). The Meth model had a higher spatial and temporal variance of DFs and lower measured organization levels compared with the other AF models, and it was the only model to show a linear relationship between the highest DF and dispersion ( R\n                    <jats:sup>2<\/jats:sup>\n                    = 0.86). These data indicate that structural remodeling of atria (models known to have predominantly altered conduction) leads to an AF characterized by a stable high-frequency area, whereas electrical remodeling of atria (models known to have predominantly shortened refractoriness without significant conduction abnormalities) leads to an AF characterized by multiple high-frequency areas and multiple wavelets.\n                  <\/jats:p>","DOI":"10.1152\/ajpheart.01128.2005","type":"journal-article","created":{"date-parts":[[2006,7,29]],"date-time":"2006-07-29T01:06:31Z","timestamp":1154135191000},"page":"H2911-H2923","source":"Crossref","is-referenced-by-count":95,"title":["Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling"],"prefix":"10.1152","volume":"291","author":[{"suffix":"IV","given":"Thomas H.","family":"Everett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Verheule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Foreman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Olgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00258-4"},{"key":"R2","unstructured":"Allessie M\n                      , Lammers WJEP, Bonke FIM, and Hollen J.\n                      Experimental evaluation of Moe's multiple wavelet hypothesis of atrial fibrillation. In:\n                      Cardiac Electrophysiology and Arrhythmias\n                      , edited by Zipes DP and Jalife J. Orlando, FL: Grune and Straton, 1985, p. 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T\n                      , Drury AN, and Lliescu CC.\n                      Further observations upon the state of rapid re-excitation of the auricles.\n                      Heart\n                      8\n                      : 311\u2013340, 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