{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:23:54Z","timestamp":1790389434095,"version":"4.1.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:p>Volatile anesthetics stimulate, but hyperglycemia attenuates, the activity of mitochondrial ATP-regulated K<jats:sup>+<\/jats:sup>channels. We tested the hypothesis that diabetes mellitus interferes with isoflurane-induced preconditioning. Acutely instrumented, barbiturate-anesthetized dogs were randomly assigned to receive 0, 0.32, or 0.64% end-tidal concentrations of isoflurane in the absence or presence of diabetes (3 wk after administration of alloxan and streptozotocin) in six experimental groups. All dogs were subjected to a 60-min left anterior descending coronary artery occlusion followed by 3 h of reperfusion. Myocardial infarct size (triphenyltetrazolium staining) was 29 \u00b1 3% ( n = 8) of the left ventricular area at risk in control experiments. Isoflurane reduced infarct size (15 \u00b1 2 and 13 \u00b1 1% during 0.32 and 0.64% concentrations; n = 8 and 7 dogs, respectively). Diabetes alone did not alter infarct size (30 \u00b1 3%; n = 8) but blocked the protective effects of 0.32% (27 \u00b1 2%; n = 7) and not 0.64% isoflurane (18 \u00b1 3%; n = 7). Infarct size was directly related to blood glucose concentrations in diabetic dogs, but this relationship was abolished by higher concentrations of isoflurane. The results indicate that blood glucose and end-tidal isoflurane concentrations are important determinants of infarct size during anesthetic-induced preconditioning.<\/jats:p>","DOI":"10.1152\/ajpheart.01130.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:03:02Z","timestamp":1425412982000},"page":"H2018-H2023","source":"Crossref","is-referenced-by-count":79,"title":["Isoflurane-induced preconditioning is attenuated by diabetes"],"prefix":"10.1152","volume":"282","author":[{"given":"Katsuya","family":"Tanaka","sequence":"first","affiliation":[{"name":"Departments of Anesthesiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Kehl","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Gu","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Krolikowski","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Pagel","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and"},{"name":"Clement J. 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