{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:16:50Z","timestamp":1773422210223,"version":"3.50.1"},"reference-count":22,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p> Angiotensin II is known to stimulate angiogenesis in the peripheral circulation through activation of the angiotensin II type 1 (AT<jats:sub>1<\/jats:sub>) receptor. This study investigated the effect of angiotensin receptor blockade on cerebral cortical microvessel density. Rats (6\u20137 wk old, n = 5\u201317) were instrumented with femoral arterial and venous indwelling catheters for arterial blood pressure measurement and drug administration. Rats were treated for 3 or 14 days with the AT<jats:sub>1<\/jats:sub> receptor blocker losartan (50 mg\/day in drinking water) or vehicle. Brains were sectioned and immunostained for CD31, and microvessel density was measured. Treatment with losartan for 3 or 14 days resulted in a slight decrease in mean arterial blood pressure (3 days, 92 \u00b1 1 mmHg; and 14 days, 99 \u00b1 2 mmHg) compared with vehicle (109 \u00b1 3 and 125 \u00b1 4 mmHg, respectively). A furosemide + captopril 14-day treatment group was added to control for the blood pressure change (96 \u00b1 3 mmHg). Microvessel density increased in groups treated with losartan for 14 days (429 \u00b1 13 vessels\/mm<jats:sup>2<\/jats:sup>) compared with vehicle (383 \u00b1 11 vessels\/mm<jats:sup>2<\/jats:sup>) but did not change with furosemide + captopril (364 \u00b1 7 vessels\/mm<jats:sup>2<\/jats:sup>). Thus AT<jats:sub>1<\/jats:sub> receptor blockade for 14 days resulted in increased cerebral microvessel density in a blood pressure-independent manner. <\/jats:p>","DOI":"10.1152\/ajpheart.01136.2004","type":"journal-article","created":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:25:14Z","timestamp":1128126314000},"page":"H512-H516","source":"Crossref","is-referenced-by-count":36,"title":["Chronic angiotensin II AT<sub>1<\/sub> receptor blockade increases cerebral cortical microvessel density"],"prefix":"10.1152","volume":"290","author":[{"given":"Diane H.","family":"Munzenmaier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1021\/bi972863j"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08089-3"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.11.2391"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16645"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00839.2004"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.88.1.22"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(95)00068-M"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000115162.16321.AA"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000027274.03779.F3"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.27.3.760"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6282"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.1.120"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.2102"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000019892.41157.24"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117710"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.261.3.H667"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)91723-P"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200308000-00001"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1159\/000054590"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0601com"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-6015-5_19"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00019-2"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.01136.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T19:29:16Z","timestamp":1567970956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.01136.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1152\/ajpheart.01136.2004"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.01136.2004","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}