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A 20-MHz probe was held by an alligator clip and positioned over the carotid arteries of 16 mice, including six 3- to 5-mo-old wild-type (WT), four 30-mo-old senescent (old), two apolipoprotein E null (ApoE), and four \u03b1-smooth muscle actin null (\u03b1-SMA) mice. Doppler signals were obtained simultaneously from both vessel walls and from blood flow. The calculated displacement signals from the near and far walls were subtracted to generate a diameter signal from which the excursion and an augmentation index were calculated. The excursion ranged between 13 \u03bcm (in ApoE) and 95 \u03bcm (in \u03b1-SMA). The augmentation index was lowest in the WT mice (0.06) and highest in the old mice (0.29). We conclude that Doppler signal processing may be used to measure vessel wall motion in mice with high spatial and temporal resolution and that diameter signals can replace pressure signals for calculating the augmentation index. This noninvasive method is able to identify and confirm characteristic changes in arterial properties previously associated with age, atherosclerosis, and the absence of vascular tone. <\/jats:p>","DOI":"10.1152\/ajpheart.01185.2003","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T15:07:33Z","timestamp":1092841653000},"page":"H1426-H1432","source":"Crossref","is-referenced-by-count":23,"title":["Noninvasive ultrasonic measurement of arterial wall motion in mice"],"prefix":"10.1152","volume":"287","author":[{"given":"Craig J.","family":"Hartley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anilkumar K.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sridhar","family":"Madala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Entman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lloyd H.","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Taffet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00070.2003"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90240-P"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.257.2.H375"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118512"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(00)00330-6"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.3.H1411"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(97)80008-9"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Georgakopoulos D, Mitzner WA, Chen CH, Byrne BJ, Millar HD, Hare JM, and Kass DA. 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