{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:45:19Z","timestamp":1789397119009,"version":"build-2803163510"},"reference-count":44,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p> We investigated how exercise training superimposed on chronic hypertension impacted left ventricular remodeling. Cardiomyocyte hypertrophy, apoptosis, and proliferation in hearts from female spontaneously hypertensive rats (SHRs) were examined. Four-month-old SHR animals were placed into a sedentary group (SHR-SED; n = 18) or a treadmill running group (SHR-TRD, 20 m\/min, 1 h\/day, 5 days\/wk, 12 wk; n = 18). Age-matched, sedentary Wistar Kyoto (WKY) rats were controls ( n = 18). Heart weight was greater in SHR-TRD vs. both WKY ( P &lt; 0.01) and SHR-SED ( P &lt; 0.05). Morphometric-derived left ventricular anterior, posterior, and septal wall thickness were increased in SHR-SED relative to WKY and augmented in SHR-TRD. Cardiomyocyte surface area, length, and width were increased in SHR-SED relative to WKY and further increased in SHR-TRD. Calcineurin abundance was increased in SHR-SED vs. WKY ( P &lt; 0.001) and attenuated in SHR-TRD relative to SHR-SED ( P &lt; 0.05). Protein abundance and mRNA of Akt was not different among groups. The rate of apoptosis was increased in SHR-SED relative to WKY and mitigated in SHR-TRD. The abundance of Ki-67<jats:sup>+<\/jats:sup> cells across groups was not statistically different across groups. The abundance of cardiac progenitor cells (c-Kit<jats:sup>+<\/jats:sup> cells) was increased in SHR-TRD relative to WKY. These data suggest that exercise training superimposed on hypertension augmented cardiomyocyte hypertrophy, despite attenuating calcineurin abundance. Exercise training also mitigated apoptosis in hypertension and showed a tendency to enhance the abundance of cardiac progenitor cells, resulting in a more favorable cardiomyocyte number in the exercise-trained hypertensive heart. <\/jats:p>","DOI":"10.1152\/ajpheart.01253.2008","type":"journal-article","created":{"date-parts":[[2009,8,8]],"date-time":"2009-08-08T01:54:52Z","timestamp":1249696492000},"page":"H1361-H1368","source":"Crossref","is-referenced-by-count":32,"title":["Left ventricular remodeling with exercise in hypertension"],"prefix":"10.1152","volume":"297","author":[{"given":"Stephen C.","family":"Kolwicz","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"MacDonnell","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut; 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