{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T14:13:16Z","timestamp":1780841596682,"version":"3.54.1"},"reference-count":46,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>Important sex differences in cardiovascular disease outcomes exist, including conditions of hypertrophic cardiomyopathy and cardiac ischemia. Studies of sex differences in the extent to which load-independent (primary) hypertrophy modulates the response to ischemia-reperfusion (I\/R) damage have not been characterized. We have previously described a model of primary genetic cardiac hypertrophy, the hypertrophic heart rat (HHR). In this study the sex differences in HHR cardiac function and responses to I\/R [compared to control normal heart rat (NHR)] were investigated ex vivo. The ventricular weight index was markedly increased in HHR female (7.82 \u00b1 0.49 vs. 4.80 \u00b1 0.10 mg\/g; P &lt; 0.05) and male (5.76 \u00b1 0.22 vs. 4.62 \u00b1 0.07 mg\/g; P &lt; 0.05) hearts. Female hearts of both strains exhibited a reduced basal contractility compared with strain-matched males [maximum first derivative of pressure (dP\/d t<jats:sub>max<\/jats:sub>): NHR, 4,036 \u00b1 171 vs. 4,258 \u00b1 152 mmHg\/s; and HHR, 3,974 \u00b1 160 vs. 4,540 \u00b1 259 mmHg\/s; P &lt; 0.05]. HHR hearts were more susceptible to I\/R (I = 25 min, and R = 30 min) injury than NHR hearts (decreased functional recovery, and increased lactate dehydrogenase efflux). Female NHR hearts exhibited a significantly greater recovery (dP\/d t<jats:sub>max<\/jats:sub>) post-I\/R relative to male NHR (95.0 \u00b1 12.2% vs. 60.5 \u00b1 9.4%), a resistance to postischemic dysfunction not evident in female HHR (29.0 \u00b1 5.6% vs. 25.9 \u00b1 6.3%). Ventricular fibrillation was suppressed, and expression levels of Akt and ERK1\/2 were selectively elevated in female NHR hearts. Thus the occurrence of load-independent primary cardiac hypertrophy undermines the intrinsic resistance of female hearts to I\/R insult, with the observed abrogation of endogenous cardioprotective signaling pathways consistent with a potential mechanistic role in this loss of protection.<\/jats:p>","DOI":"10.1152\/ajpheart.01283.2007","type":"journal-article","created":{"date-parts":[[2008,2,2]],"date-time":"2008-02-02T02:22:12Z","timestamp":1201918932000},"page":"H1514-H1522","source":"Crossref","is-referenced-by-count":33,"title":["The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy"],"prefix":"10.1152","volume":"294","author":[{"given":"James R.","family":"Bell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo R.","family":"Porrello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Huggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Harrap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea M. D.","family":"Delbridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.67.4.948"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.090803"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.02.015"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Bell JR, Eaton P, Shattock MJ.Role of p38-mitogen-activated protein kinase in ischaemic preconditioning in rat heart.Clin Exp Pharmacol Physiol35: 126\u2013134, 2007.","DOI":"10.1111\/j.1440-1681.2007.04794.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(02)00310-3"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Besik J, Szarszoi O, Kunes J, Netuka I, Maly J, Kolar F, Pirk J, Ostadal B.Tolerance to acute ischemia in adult male and female spontaneously hypertensive rats.Physiol Res56: 267\u2013274, 2007.","DOI":"10.33549\/physiolres.930998"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S1550-8579(04)80014-7"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1161\/hh1001.090858"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.12.1215"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00528-4"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00790.2001"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/s004240000473"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.05.014"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1418"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.6.660"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.11.013"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.3.380"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00070.2006"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00006.2002"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.06.010"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500684200"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.04.001"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319429"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi443"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.3.330"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.03.002"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04585.x"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.054"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00701-0"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.11.019"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.01.014"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00377.2006"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.10.041"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi653"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-6-8"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2003.01068.x"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-3-200102060-00007"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/22.7.447"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00278.2004"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01219.2005"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.09.014"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00705-8"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.6.H2766"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.01283.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T07:34:31Z","timestamp":1630654471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.01283.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1152\/ajpheart.01283.2007"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.01283.2007","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}