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Hypertrophic growth is believed to have a compensatory role that diminishes wall stress and oxygen consumption, but Framingham and other studies established ventricular hypertrophy as a marker for increased risk of developing chronic heart failure, suggesting that hypertrophy may have maladaptive features. However, the relative contribution of comorbid disease to hypertrophy-associated systolic failure is unknown. For instance, coronary artery disease is induced by many of the same risk factors that cause hypertrophy and can itself lead to systolic dysfunction. It is uncertain, therefore, whether ventricular hypertrophy commonly progresses to systolic dysfunction without the contribution of intervening ischemia or infarction. In this review, we summarize findings from epidemiologic studies, preclinical experiments in animals, and clinical trials to lay out what is known\u2014and not known\u2014about this important question. <\/jats:p>","DOI":"10.1152\/ajpheart.01303.2004","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T21:33:19Z","timestamp":1118871199000},"page":"H8-H16","source":"Crossref","is-referenced-by-count":166,"title":["Does load-induced ventricular hypertrophy progress to systolic heart failure?"],"prefix":"10.1152","volume":"289","author":[{"given":"Kambeez","family":"Berenji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Drazner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly A.","family":"Rothermel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5363.574"},{"key":"R2","unstructured":"American Heart Association. 2002 Heart and Stroke Statistical Update. 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