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Basal and hyperemic (intravenous dipyridamole) perfusion measurements were obtained with [<jats:sup>13<\/jats:sup>N]ammonia positron emission tomographic imaging in left (LV) and right (RV) ventricular and septal myocardium in 14 adults with CCHD [age: 34.1 yr (SD 6.5)]; hematocrit: 62.2% (SD 4.8)] and 10 healthy controls [age: 34.1 yr (SD 6.5)]. In patients, basal perfusion measurements were higher in LV [0.77 (SD 0.24) vs. 0.55 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g<jats:sup>\u22121<\/jats:sup> (SD 0.09), P &lt; 0.02], septum [0.71 (SD 0.16) vs. 0.49 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g<jats:sup>\u22121<\/jats:sup> (SD 0.09), P &lt; 0.001], and RV [0.77 (SD 0.30) vs. 0.38 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g<jats:sup>\u22121<\/jats:sup> (SD 0.09), P &lt; 0.001]. However, basal measurements normalized for the rate-pressure product were similar to those of controls. Calculated oxygen delivery relative to rate-pressure product was higher in the patients [2.2 (SD 0.8) vs. 1.6 (SD 0.4) \u00d7 10<jats:sup>\u22125<\/jats:sup> ml O<jats:sub>2<\/jats:sub>\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g tissue<jats:sup>\u22121<\/jats:sup>\u00b7(beats\u00b7mmHg)<jats:sup>\u22121<\/jats:sup> in the LV, P &lt; 0.05, and 2.0 (SD 0.7) vs. 1.4 (SD 0.3) \u00d7 10<jats:sup>\u22125<\/jats:sup> ml O<jats:sub>2<\/jats:sub>\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g tissue<jats:sup>\u22121<\/jats:sup>\u00b7(beats\u00b7mmHg)<jats:sup>\u22121<\/jats:sup> in the septum, P &lt; 0.01]. Hyperemic perfusion measurements in CCHD patients did not differ from controls [LV, 1.67 (SD 0.60) vs. 1.95 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g<jats:sup>\u22121<\/jats:sup> (SD 0.46); septum, 1.44 (SD 0.56) vs. 1.98 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g<jats:sup>\u22121<\/jats:sup> (SD 0.69); RV, 1.56 (SD 0.56) vs. 1.65 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7g<jats:sup>\u22121<\/jats:sup> (SD 0.64), P = not significant], and coronary vascular resistances were comparable [LV, 55 (SD 25) vs. 48 mmHg\u00b7ml<jats:sup>\u22121<\/jats:sup>\u00b7g\u00b7min (SD 16); septum, 67 (SD 35) vs. 50 mmHg\u00b7ml<jats:sup>\u22121<\/jats:sup>\u00b7g\u00b7min (SD 21); RV, 59 (SD 26) vs. 61 mmHg\u00b7ml<jats:sup>\u22121<\/jats:sup>\u00b7g\u00b7min (SD 27), P = not significant]. These findings suggest that adult CCHD patients have remodeling of the coronary circulation to compensate for the rheologic changes attending chronic hypoxemia. <\/jats:p>","DOI":"10.1152\/ajpheart.01309.2004","type":"journal-article","created":{"date-parts":[[2005,7,9]],"date-time":"2005-07-09T00:25:55Z","timestamp":1120868755000},"page":"H1798-H1806","source":"Crossref","is-referenced-by-count":17,"title":["Myocardial perfusion reserve in adults with cyanotic congenital heart disease"],"prefix":"10.1152","volume":"289","author":[{"given":"Richard C.","family":"Brunken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph K.","family":"Perloff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Czernin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Campisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela D.","family":"Miner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Child","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich R.","family":"Schelbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02985-0"},{"key":"R2","unstructured":"Arias-Stella J and Topilsky M. 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