{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T07:19:30Z","timestamp":1648970370709},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[1981,2,1]]},"abstract":"<jats:p> Circulatory effects of small (approximately 10%) changes in blood volume were examined in resting and exercising dogs: controls; group A (-200 ml blood); group B (+200 ml blood); group C (+200 ml 6% dextran). In exercise, cardiac output (Q) increased more in Group A than controls (510.4 ml . kg-1 . min-1 compared to 429.6 ml . kg-1 . min-1; P less than 0.05); oxygen delivery (cardiac output x arterial O2 content) and mixed venous oxygen tension (PVO2) were unchanged from exercising controls. Hypervolemia (group B) did not change Q or O2 delivery compared to controls, but caused a greater reduction in exercise PVO2 (29.3 mmHg compared to 33.1 mmHg in controls; P less than 0.01). Resting PVO2 as raised in group C (50.0 mmHg compared to 46.3 mmHg; P less than 0.05) and exercise PVO2 was reduced less (35.5 mmHg compared to 33.1 mmHg in controls; P less than 0.05). O2 delivery in exercise was higher than in controls (123.4 ml . kg-1 . min-1 compared to 94.3 ml . kg-1 . min-1; P less than 0.001). During exercise, O2 consumption was raised from base line to 34.9 ml . kg-1 . min-1 in controls and raised further to 41.4 ml . kg-1 . min-1 in group A, 44.4 ml . kg-1 . min-1 in group B, and 41.2 ml . kg-1 . min-1 in group C (P less than 0.01). Changes of blood volume that lie within physiological limits thus significantly modify the circulatory response to changed O2 requirements, and also change the metabolic cost of exercise. <\/jats:p>","DOI":"10.1152\/ajpheart.1981.240.2.h177","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T01:00:41Z","timestamp":1514163641000},"page":"H177-H184","source":"Crossref","is-referenced-by-count":1,"title":["Effects of small changes of blood volume on oxygen delivery and tissue oxygenation"],"prefix":"10.1152","volume":"240","author":[{"given":"I. H.","family":"Sarelius","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.1981.240.2.H177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:40:40Z","timestamp":1568000440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.1981.240.2.H177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,2,1]]}},"alternative-id":["10.1152\/ajpheart.1981.240.2.H177"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.1981.240.2.h177","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,2,1]]}}}