{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T19:55:48Z","timestamp":1649015748820},"reference-count":26,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:p> In severe congestive heart failure (CHF), abnormal reflex control of calf blood flow during brief head-up tilt that appears to normalize after transplantation (HTX) may be present during prolonged observation also. Therefore, we studied the effect of prolonged (30 min) 50\u00b0 head-up tilt on calf skeletal muscle blood flow measured by the local<jats:sup>133<\/jats:sup>Xe washout method in CHF and after HTX and in patients with the presence vs. absence of native right atrium (+PNA and \u2212PNA, respectively). During brief head-up tilt, skeletal muscle blood flow increased 13 \u00b1 42% in 9 severe CHF patients in contrast to a \u221228 \u00b1 22% decrease ( P &lt; 0.01) in 11 control subjects, \u221224 \u00b1 30% decrease in 15 moderate CHF patients ( P &lt; 0.05), \u221225 \u00b1 14% decrease in 12 patients with recent HTX ( P &lt; 0.01), and \u221221 \u00b1 24% decrease in 8 patients with distant HTX ( P = 0.06). However, during sustained tilt, blood flow declined to similar levels of that in the other groups in severe CHF. HTX \u2212PNA vs. +PNA showed blunted skeletal muscle vasomotor control ( P &lt; 0.05) and a higher systolic blood pressure (139 \u00b1 14 vs. 125 \u00b1 15 mmHg, P &lt; 0.05) and heart rate (92 \u00b1 10 vs. 83 \u00b1 8 beats\/min, P &lt; 0.05). Thus paradox vasodilatation of calf skeletal muscle in severe CHF is present only during brief but not prolonged tilt. This may be one explanation of the rare presence of orthostatic intolerance in CHF and implies only a minor possible role for the abnormality in edema pathogenesis. Removal of all right atrium in HTX has an important hemodynamic impact that may possibly affect later clinical outcome. <\/jats:p>","DOI":"10.1152\/ajpheart.2000.278.1.h239","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T07:05:43Z","timestamp":1513926343000},"page":"H239-H248","source":"Crossref","is-referenced-by-count":2,"title":["Calf blood flow during prolonged tilt in idiopathic dilated  cardiomyopathy and after cardiac transplantation"],"prefix":"10.1152","volume":"278","author":[{"given":"S\u00f8ren","family":"Galatius","sequence":"first","affiliation":[{"name":"The Heart Center, The Rigshospital, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Wroblewski","sequence":"additional","affiliation":[{"name":"The Heart Center, The Rigshospital, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke B.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"The Heart Center, The Rigshospital, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bie","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, The Panum Institute, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Arendrup","sequence":"additional","affiliation":[{"name":"The Heart Center, The Rigshospital, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Kastrup","sequence":"additional","affiliation":[{"name":"The Heart Center, The Rigshospital, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.12.4273"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.14.1368"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.1.72"},{"key":"B5","first-page":"110","volume":"3","author":"Cabrol C.","year":"1984","journal-title":"Heart Transplant."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.4.604"},{"key":"B7","first-page":"164","volume":"314","author":"Cotts W. 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