{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:37:38Z","timestamp":1791077858762,"version":"4.1.0"},"reference-count":33,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:p>This study was aimed to investigate the underlying mechanism of vasodilation induced by the activation of A<jats:sub>2B<\/jats:sub>adenosine receptors in relation to cerebral blood flow (CBF) autoregulation. Changes in pial arterial diameters were observed directly through a closed cranial window. N<jats:sup>\u03c9<\/jats:sup>-nitro-l-arginine methyl ester (l-NAME, nitric oxide synthase inhibitor) significantly suppressed the concentration-dependent vasodilations induced by adenosine and 5\u2032- N-ethylcarboxamido-adenosine (NECA) but not the vasodilation by CGS-21680 (A<jats:sub>2A<\/jats:sub>-receptor agonist). Moreover, NECA-induced vasodilation was suppressed by alloxazine (1 \u03bcmol\/l) but not by ZM-241385 (1 \u03bcmol\/l, A<jats:sub>2A<\/jats:sub>antagonist), which suggests mediation by A<jats:sub>2B<\/jats:sub>- receptor activation. Otherwise, the level of nitrite\/nitrate was concentration dependently increased in the artificial cerebrospinal fluid (CSF) when adenosine and NECA were suffused over the cortical surface.l-NAME and alloxazine, but not ZM-241385, largely inhibited their releases. The lower limit of CBF autoregulation was little affected following pretreatment with l-NAME or alloxazine. Thus it is suggested that adenosine-induced vasodilation via activation of A<jats:sub>2B<\/jats:sub>-adenosine receptors of the rat pial artery is coupled to the production of nitric oxide, which contributes little to CBF autoregulation.<\/jats:p>","DOI":"10.1152\/ajpheart.2000.278.2.h339","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T06:52:44Z","timestamp":1513925564000},"page":"H339-H344","source":"Crossref","is-referenced-by-count":46,"title":["Role of adenosine A<sub>2B<\/sub>receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation"],"prefix":"10.1152","volume":"278","author":[{"given":"Hwa Kyoung","family":"Shin","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Woo","family":"Shin","sequence":"additional","affiliation":[{"name":"Internal Medicine, College of Medicine, Pusan National University, Pusan 602-739; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Whan","family":"Hong","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and"},{"name":"Center for Biofunctional Molecules, Pohang University of Science and Technology, Pohang 790-600, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90480-4"},{"key":"B2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0026-895X(25)10259-9","volume":"29","author":"Bruns R. 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