{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T04:40:02Z","timestamp":1751172002360,"version":"3.41.0"},"reference-count":22,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"This study was designed to characterize the role of the newly described endogenous opioid nociceptin\/orphanin FQ (NOC\/oFQ) in reduced cerebral blood flow (CBF) observed after ischemia-reperfusion (I\/R) and combined hypoxia and ischemia-reperfusion (H-I\/R), as a function of time after onset of reperfusion in newborn pigs equipped with a closed cranial window. Global cerebral ischemia (20 min) was induced via elevation of intracranial pressure, whereas hypoxia (10 min) decreased[Formula: see text] to 35 \u00b1 3 mmHg with unchanged[Formula: see text]. I\/R elevated cerebrospinal fluid (CSF) NOC\/oFQ from 67 \u00b1 4 to 266 \u00b1 29 pg\/ml within 1 h, whereas values returned to control level within 4 h of reperfusion. H-I\/R elevated CSF NOC\/oFQ to 483 \u00b1 67 pg\/ml within 1 h, and such values returned slowly to control level within 12 h of reperfusion. Topical NOC\/oFQ (10\u2212<\/jats:sup>8<\/jats:sup>M, 10\u2212<\/jats:sup>6<\/jats:sup>M)-induced vasodilation was attenuated by I\/R and reversed to vasoconstriction by H-I\/R at 1 h of reperfusion (control, 9 \u00b1 1 and 16 \u00b1 1%; I\/R, 3 \u00b1 1 and 6 \u00b1 1%; H-I\/R, \u22126 \u00b1 1 and \u221211 \u00b1 1%). Such altered dilation returned to control values within 4 h in I\/R animals and within 12 h in H-I\/R animals. Blood flow in the cerebrum was reduced from 58 \u00b1 4 to 33 \u00b1 2 ml \u22c5 min\u2212<\/jats:sup>1<\/jats:sup>\u22c5 100 g\u2212<\/jats:sup>1<\/jats:sup>within 1 h and returned to control value within 4 h in I\/R animals. In animals pretreated with [F\/G]NOC\/oFQ(1\u201313)-NH2<\/jats:sub>(1 mg\/kg iv), an NOC\/oFQ antagonist, however, CBF only fell to 43 \u00b1 3 ml \u22c5 min\u2212<\/jats:sup>1<\/jats:sup>\u22c5 100 g\u2212<\/jats:sup>1<\/jats:sup>at 1 h of reperfusion. Similar observations were made in H-I\/R animals. These data suggest that an elevated CSF NOC\/oFQ concentration and altered vascular responsiveness to this opioid contribute to reductions in CBF observed after either I\/R or H-I\/R.<\/jats:p>","DOI":"10.1152\/ajpheart.2000.278.2.h477","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T06:52:44Z","timestamp":1513925564000},"page":"H477-H483","source":"Crossref","is-referenced-by-count":13,"title":["Relationship between nociceptin\/orphanin FQ and cerebral hemodynamics after hypoxia-ischemia in piglets"],"prefix":"10.1152","volume":"278","author":[{"given":"William M.","family":"Armstead","sequence":"first","affiliation":[{"name":"Departments of Anesthesia and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.268.1.H226"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.67"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-214-44089"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01623-6"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00561-3"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(98)00117-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00560-5"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(97)00014-4"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(97)00178-2"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)80603-9"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01128-X"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701640"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00696-0"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/377476a0"},{"key":"B15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0022-3565(24)38120-0","volume":"289","author":"Kapusta D. R.","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198902000-00020"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.4.541"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.257.6.H1917"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01411-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/377532a0"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)80235-1"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5237.792"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.2000.278.2.H477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T04:04:13Z","timestamp":1751169853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.2000.278.2.H477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2,1]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2,1]]}},"alternative-id":["10.1152\/ajpheart.2000.278.2.H477"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.2000.278.2.h477","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"type":"print","value":"0363-6135"},{"type":"electronic","value":"1522-1539"}],"subject":[],"published":{"date-parts":[[2000,2,1]]}}}