{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:10:12Z","timestamp":1791245412600,"version":"4.1.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2000,3,1]]},"abstract":"<jats:p> We applied spectral techniques to the analysis of cardiorespiratory signals [instantaneous lung volume (ILV), instantaneous tidal volume (ITV), arterial O<jats:sub>2<\/jats:sub> saturation ([Formula: see text]) at the ear, heart rate (HR), systolic (SAP), and diastolic (DAP) arterial pressure] during nonapneic periodic breathing (PB) in 29 awake chronic heart failure (CHF) patients and estimated the timing relationships between respiratory and slow cardiovascular (&lt;0.04 Hz) oscillations. Our aim was 1) to elucidate major mechanisms involved in cardiorespiratory interactions during PB and 2) to test the hypothesis of a central vasomotor origin of PB. All cardiovascular signals were characterized by a dominant (\u226584% of total power) oscillation at the frequency of PB (mean \u00b1 SE: 0.022 \u00b1 0.0008 Hz), highly coherent (\u22650.89), and delayed with respect to ITV (ITV-HR, 2.4 \u00b1 0.72 s; ITV-SAP, 6.7 \u00b1 0.65 s; ITV-DAP, 3.2 \u00b1 0.61 s; P &lt; 0.01). [Formula: see text] was highly coherent with (coherence function = 0.96 \u00b1 0.009) and almost opposite in phase to ITV. These findings demonstrate the existence of a generalized cardiorespiratory rhythm led by the ventilatory oscillation and suggest that 1) the cyclic increase in inspiratory drive and cardiopulmonary reflexes and 2) mechanical effects of PB-induced changes in intrathoracic pressure are the more likely sources of the HR and blood pressure oscillations, respectively. The timing relationship between ITV and blood pressure signals excludes the possibility that PB represents the effect of a central vasomotor rhythm. <\/jats:p>","DOI":"10.1152\/ajpheart.2000.278.3.h932","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T01:50:00Z","timestamp":1513907400000},"page":"H932-H941","source":"Crossref","is-referenced-by-count":34,"title":["Cardiorespiratory interactions during periodic  breathing in awake chronic heart failure patients"],"prefix":"10.1152","volume":"278","author":[{"given":"G. 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