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A significant protection against ischemia-reperfusion injury was observed 48 h after HS as demonstrated by: 1) reduction in infarct size; 2) decrease in leakage of lactate dehydrogenase; and 3) enhanced postischemic ventricular contractile function. No such protection was observed at other post-HS time points. HS caused an \u223c25% increase in phosphorylated c-Jun NH<jats:sub>2<\/jats:sub>-terminal kinase (JNK) but not p38 MAPK in the heart during the first 2-h post-HS time period. Cardioprotection was abolished by the MAPK inhibitor SB-203580, which also partially suppressed the HS-induced JNK phosphorylation. The protective effect was associated with a two- to threefold increase in HSP72 protein accumulation, but not antioxidant enzyme activities (catalase and Cu\/Zn and Mn SOD) in the myocardium. Although HSP72 levels remained high 72 h after HS, the cardioprotection had already disappeared. We conclude that HS induces a transient delayed cardioprotection at 48 h after thermal stress in mice which appears to be mediated via a MAPK-signaling pathway.<\/jats:p>","DOI":"10.1152\/ajpheart.2001.281.2.h523","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T19:45:32Z","timestamp":1513971932000},"page":"H523-H532","source":"Crossref","is-referenced-by-count":26,"title":["Mitogen-activated protein kinases mediate heat shock-induced delayed protection in mouse heart"],"prefix":"10.1152","volume":"281","author":[{"given":"Demet","family":"Tekin","sequence":"first","affiliation":[{"name":"Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia 23298"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia 23298"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingcun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia 23298"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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