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ET-1 produced a concentration-dependent contraction of the rabbit basilar artery in the normal Cl<jats:sup>\u2212<\/jats:sup>Krebs-Henseleit bicarbonate buffer (123 mM Cl<jats:sup>\u2212<\/jats:sup>). The ET-1-induced contraction was reduced by the following manipulations: 1) inhibition of Na<jats:sup>+<\/jats:sup>-K<jats:sup>+<\/jats:sup>-2Cl<jats:sup>\u2212<\/jats:sup>cotransporter with bumetanide (3 \u00d7 10<jats:sup>\u22125<\/jats:sup>and 10<jats:sup>\u22124<\/jats:sup>M), 2) bicarbonate-free solution to disable Cl<jats:sup>\u2212<\/jats:sup>\/HCO[Formula: see text] exchanger, and 3) preincubation of rings with the Cl<jats:sup>\u2212<\/jats:sup>channel blockers niflumic acid, 5-nitro-2-(3-phenylpropylamino)benzoic acid, and indanyloxyacetic acid 94. The ET-1-induced contraction was enhanced by substitution of extracellular Cl<jats:sup>\u2212<\/jats:sup>(10 mM) with methanesulfonic acid (113 mM). Cl<jats:sup>\u2212<\/jats:sup>channels are involved in ET-1-induced contraction in the rabbit basilar artery.<\/jats:p>","DOI":"10.1152\/ajpheart.2001.281.5.h2159","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T19:22:45Z","timestamp":1513970565000},"page":"H2159-H2167","source":"Crossref","is-referenced-by-count":15,"title":["Role of Cl<sup>\u2212<\/sup>current in endothelin-1-induced contraction in rabbit basilar artery"],"prefix":"10.1152","volume":"281","author":[{"given":"Yun","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi 39216"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi 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