{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:32:11Z","timestamp":1792657931822,"version":"4.5.0"},"reference-count":29,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p> Inherent in the remote organ injury caused by sepsis is a profound maldistribution of microvascular blood flow. Using a 24-h rat cecal ligation and perforation model of sepsis, we studied O<jats:sub>2<\/jats:sub> transport in individual capillaries of the extensor digitorum longus (EDL) skeletal muscle. We hypothesized that erythrocyte O<jats:sub>2<\/jats:sub> saturation (So <jats:sub>2<\/jats:sub>) levels within normally flowing capillaries would provide evidence of either a mitochondrial failure (increased So <jats:sub>2<\/jats:sub>) or an O<jats:sub>2<\/jats:sub> transport derangement (decreased So <jats:sub>2<\/jats:sub>). Using a spectrophotometric functional imaging system, we found that sepsis caused 1) an increase in stopped flow capillaries (from 10 to 38%, P &lt; 0.05), 2) an increase in the proportion of fast-flow to normal-flow capillaries ( P&lt; 0.05), and 3) a decrease in capillary venular-end So <jats:sub>2<\/jats:sub> levels from 58.4 \u00b1 20.0 to 38.5 \u00b1 21.2%, whereas capillary arteriolar-end So <jats:sub>2<\/jats:sub>levels remained unchanged compared with the sham group. Capillary O<jats:sub>2<\/jats:sub> extraction increased threefold ( P &lt; 0.05) and was directly related to the degree of stopped flow in the EDL. Thus impaired O<jats:sub>2<\/jats:sub> transport in early stage sepsis is likely the result of a microcirculatory dysfunction. <\/jats:p>","DOI":"10.1152\/ajpheart.2002.282.1.h156","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T20:28:10Z","timestamp":1513974490000},"page":"H156-H164","source":"Crossref","is-referenced-by-count":215,"title":["Effect of a maldistribution of microvascular blood  flow on capillary O<sub>2<\/sub> extraction in sepsis"],"prefix":"10.1152","volume":"282","author":[{"given":"Christopher G.","family":"Ellis","sequence":"first","affiliation":[{"name":"Vascular Biology Program, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6B 1B8; Departments of"},{"name":"Medical Biophysics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryon M.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6B 1B8; 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