{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:51:00Z","timestamp":1778701860172,"version":"3.51.4"},"reference-count":17,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2002,3,1]]},"abstract":"<jats:p> All elements of the renin-angiotensin system (RAS) are present in the forebrain, particularly in circumventricular organs surrounding the third cerebral ventricle. We tested the hypothesis that forebrain angiotensin-converting enzyme (ACE) has a tonic excitatory influence on sympathetic drive. Neurally intact and sinoaortic-denervated pentobarbital-anesthetized rats were treated with forebrain-directed intracarotid artery (ICA) versus intravenous injections of angiotensin I (ANG I) and of the ACE inhibitor captopril. In intact rats, ICA ANG I elicited a rise in arterial pressure and a concomitant reduction in renal sympathetic nerve activity (RSNA; ICA captopril elicited the opposite responses). In barodenervated rats, ICA ANG I increased and ICA captopril decreased arterial pressure and RSNA in parallel; intravenous ANG I had no effect on RSNA. The findings suggest that the intrinsic forebrain RAS has a tonic excitatory influence on sympathetic drive that is overshadowed in normal rats by baroreflex mechanisms, but may assume a more prominent role in pathophysiological states (e.g., heart failure) in which baroreflex mechanisms are impaired and RAS activity is augmented. <\/jats:p>","DOI":"10.1152\/ajpheart.2002.282.3.h890","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T15:10:47Z","timestamp":1513955447000},"page":"H890-H895","source":"Crossref","is-referenced-by-count":26,"title":["Forebrain renin-angiotensin system has a tonic  excitatory influence on renal sympathetic nerve activity"],"prefix":"10.1152","volume":"282","author":[{"given":"Shun-Guang","family":"Wei","sequence":"first","affiliation":[{"name":"Research Service, Veterans Affairs Medical Center and Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Felder","sequence":"additional","affiliation":[{"name":"Research Service, Veterans Affairs Medical Center and Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.257.1.H314"},{"key":"B2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1054\/jcaf.2000.9501","volume":"6","author":"Bristow MR.","year":"2000","journal-title":"J Card Fail"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1996.tb03073.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90746-8"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1021\/bi00439a001"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1997.0157"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1980.239.1.H108"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1997.0153"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00877755"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01807-7"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90340-8"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.11.3.230"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1997.tb00613.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.6.R1145"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.6.R1807"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00130-3"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(05)80020-9"}],"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpheart.2002.282.3.H890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T14:57:37Z","timestamp":1567954657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpheart.2002.282.3.H890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,1]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3,1]]}},"alternative-id":["10.1152\/ajpheart.2002.282.3.H890"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.2002.282.3.h890","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,1]]}}}