{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:59:59Z","timestamp":1790870399658,"version":"4.1.0"},"reference-count":0,"publisher":"American Physiological Society","funder":[{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["289778"],"award-info":[{"award-number":["289778"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"abstract":"<jats:p>Myocardial ischemia\/reperfusion (I\/R) injury remains a major determinant of final infarct size and adverse outcomes in ST-segment elevation myocardial infarction (STEMI). Following our previous demonstration of CDP-choline-mediated cardioprotection in cultured cardiomyocytes and rodent models, the present study evaluated its efficacy in a clinically relevant closed-chest porcine model of myocardial I\/R injury.<\/jats:p>\n                  <jats:p>Sixteen Yorkshire pigs underwent 60 min of left anterior descending coronary artery occlusion followed by reperfusion and were randomized to intravenous CDP-choline (n = 8) or placebo (n = 8). CDP-choline (1,000 mg) was administered 30 min after coronary occlusion, followed by 500 mg every 12 h. The primary endpoint was infarct size assessed 24 h after reperfusion by cardiac magnetic resonance. Area at risk was quantified by T2-weighted imaging, whereas infarct size and myocardial salvage were assessed by late gadolinium enhancement.<\/jats:p>\n                  <jats:p>Baseline characteristics and area at risk were comparable between groups. CDP-choline significantly reduced absolute infarct mass (10.34 \u00b1 6.45 vs. 21.09 \u00b1 10.36 g; P=0.026), increased myocardial salvage index (65.86 \u00b1 18.72% vs. 40.42 \u00b1 17.62%; P&lt;0.05), and decreased histological infarct size (8.31 \u00b1 10.9% vs. 17.41 \u00b1 12.5%; P = 0.015). CDP-choline also reduced cumulative troponin release (AUC\u2080\u2013\u2089\u2086 h, P=0.001), demonstrated a significant treatment-by-time interaction (P=0.012), and attenuated myocardial oxidative stress.<\/jats:p>\n                  <jats:p>In this proof-of-concept study, CDP-choline reduced infarct size, enhanced myocardial salvage, and attenuated myocardial injury in a clinically relevant porcine model of myocardial I\/R. These findings support further mechanistic investigation and provide a rationale for future translational evaluation of CDP-choline as an adjunctive cardioprotective strategy during reperfusion in STEMI.<\/jats:p>","DOI":"10.1152\/ajpheart.90128.2026","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:35:24Z","timestamp":1790868924000},"update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardioprotective effects of CDP-choline in ischemia\/reperfusion injury using a swine model of acute myocardial infarction"],"prefix":"10.1152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-9963","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Gonz\u00e1lez-Pacheco","sequence":"first","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-3367","authenticated-orcid":false,"given":"Felipe","family":"Mass\u00f3","sequence":"additional","affiliation":[{"name":"UNAM-INC Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Amezcua-Guerra","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Molina-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez Mexico City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Villegas-Juache","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Abundes-Velasco","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6493-7765","authenticated-orcid":false,"given":"Regina","family":"de la Mora-Cervantes","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"},{"name":"Grupo CT Scanner,Mexico City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Herrera-Zarza","sequence":"additional","affiliation":[{"name":"Grupo CT Scanner,Mexico City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura V.","family":"Torres-Araujo","sequence":"additional","affiliation":[{"name":"Grupo CT Scanner,Mexico City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Ortega-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Zazueta","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wylly R.","family":"Garc\u00eda-Ni\u00f1o","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Correa","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Aranda-Fraustro","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Vargas-Barron","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Vargas-Estrada","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Arias-Mendoza","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Sandoval-Z\u00e1rate","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Ch\u00e1vez"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","published-online":{"date-parts":[[2026,10,1]]},"container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpheart.90128.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:35:25Z","timestamp":1790868925000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpheart.90128.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":0,"alternative-id":["10.1152\/ajpheart.90128.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpheart.90128.2026","relation":{},"ISSN":["0363-6135","1522-1539"],"issn-type":[{"value":"0363-6135","type":"print"},{"value":"1522-1539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2026-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ajpheart.90128.2026"}}