{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:51:09Z","timestamp":1758477069019},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Legacy Content"],"published-print":{"date-parts":[[1960,11,1]]},"abstract":"<jats:p> Dog heart-lung preparations were studied to determine the relationship between the toxicity of elevated potassium and the blood pH and pCO<jats:sub>2<\/jats:sub>. During hyperkalemia, a) a change from hypercapneic acidosis to hypocapneic alkalosis produced electrocardiographic deterioration after a delay of 3\u20135 minutes; cardiac function improved during alkalosis until ECG deterioration occurred; b) increase of pH produced by hypertonic bicarbonate infusion during hypercapnia improved mechanical performance; ECG also improved, even when pCO<jats:sub>2<\/jats:sub> was later decreased; c) infusion of hypertonic NaCl during hypercapnia partially prevented ECG deterioration after reduction of pCO<jats:sub>2<\/jats:sub>. These experiments indicate that potassium toxicity is aggravated by acute reduction of pCO<jats:sup>2<\/jats:sup>. This may not be due solely to the change in pH, since similar pH increase from bicarbonate infusion did not make the ECG worse. Reduction of [Ca<jats:sup>++<\/jats:sup>] by pH increase is not the cause of ECG deterioration; if it were, ECG should be more affected in bicarbonate and NaCl infusion experiments than in the others. The cause of ECG deterioration with reduction of pCO<jats:sub>2<\/jats:sub> remains unknown. <\/jats:p>","DOI":"10.1152\/ajplegacy.1960.199.5.759","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T02:41:52Z","timestamp":1513910512000},"page":"759-764","source":"Crossref","is-referenced-by-count":6,"title":["Relationship between cardiac toxicity of K and acute alterations of blood pH and pCO<sub>2<\/sub>"],"prefix":"10.1152","volume":"199","author":[{"given":"Daniel T.","family":"Young","sequence":"first","affiliation":[{"name":"Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin W.","family":"Monroe","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Craige","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Legacy Content"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplegacy.1960.199.5.759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:50:25Z","timestamp":1567961425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplegacy.1960.199.5.759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1960,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1960,11,1]]}},"alternative-id":["10.1152\/ajplegacy.1960.199.5.759"],"URL":"https:\/\/doi.org\/10.1152\/ajplegacy.1960.199.5.759","relation":{},"ISSN":["0002-9513"],"issn-type":[{"value":"0002-9513","type":"print"}],"subject":[],"published":{"date-parts":[[1960,11,1]]}}}