{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:03:33Z","timestamp":1790269413597,"version":"4.1.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:p>Pneumoconiosis is an occupational disease accompanied by long-term lung impairment, for which prediction of prognosis is poorly understood because of the complexity of the inhaled particles. Micro-proton-induced X-ray emission (micro-PIXE) analysis, which is advantageous for high-sensitivity, two-dimensional element mapping of lung tissues, was used to investigate element-based predictive factors of prognosis in Chinese patients with welder\u2019s and coal miner\u2019s pneumoconiosis. Chest radiographs and lung function tests showed that most of the coal miners deteriorated, whereas symptoms in some welders were alleviated after 5 yr, as determined by comparing percent vital capacity (%VC) and forced expiratory volume in the 1st second over forced vital capacity (FEV1.0\/FVC) to values taken at the initial diagnosis. Micro-PIXE analysis suggested that the most abundant particulates in welder\u2019s pneumoconiosis were Fe, Mn, and Ti (metallic oxide),which were accompanied by particulates containing Si, Al, and Ca (aluminum silicate) or only Si (SiO<jats:sub>2<\/jats:sub>); the most abundant particulates in coal miner\u2019s pneumoconiosis were composed of C, Si, Al, K, and Ti, which were accompanied by particulates containing Ca or Fe. Particulates containing Al, Si, S, K, Ca, and Ti (orthoclase and anorthite) were correlated with severity of fibrosis. Multivariable linear regression suggested that long-term FEV1.0\/FVC decrease was independently associated with Si and smoking index, whereas %VC decrease was associated with Si and Ti. A risk index comprised of these factors was developed to predict the prognosis of pneumoconiosis. Micro-PIXE analysis is feasible for the evaluation of elemental composition and dust exposure, especially for patients whose exposure is mixed or uncertain.<\/jats:p>","DOI":"10.1152\/ajplung.00009.2017","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T01:10:32Z","timestamp":1505437832000},"page":"L1154-L1163","source":"Crossref","is-referenced-by-count":5,"title":["Element-based prognostics of occupational pneumoconiosis using micro-proton-induced X-ray emission analysis"],"prefix":"10.1152","volume":"313","author":[{"given":"Xiaodong","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory of Applied Ion Beam Physics, Institute of Modern Physics, Fudan University, Shanghai, China"},{"name":"Department of Pneumoconiosis, Occupational Disease Clinical Research Centre, Department of Radiotherapy, Central Laboratory, Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Ion Beam Physics, Institute of Modern Physics, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zidan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pneumoconiosis, Occupational Disease Clinical Research Centre, Department of Radiotherapy, Central Laboratory, Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caicai","family":"Rong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Ion Beam Physics, Institute of Modern Physics, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqin","family":"Ren","sequence":"additional","affiliation":[{"name":"Center for Ion Beam Applications, Department of Physics, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Likun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pneumoconiosis, Occupational Disease Clinical Research Centre, Department of Radiotherapy, Central Laboratory, Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pneumoconiosis, Occupational Disease Clinical Research Centre, Department of Radiotherapy, Central Laboratory, Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pneumoconiosis, Occupational Disease Clinical Research Centre, Department of Radiotherapy, Central Laboratory, Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Lu","sequence":"additional","affiliation":[{"name":"Departments of Environmental Health, Genetics, and Complex Diseases, Harvard T. 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