{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:05:54Z","timestamp":1787313954523,"version":"build-2736575974"},"reference-count":32,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["KOPP20I0"],"award-info":[{"award-number":["KOPP20I0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL158747"],"award-info":[{"award-number":["R01 HL158747"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL148171"],"award-info":[{"award-number":["R01 HL148171"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["MCCOY19RO"],"award-info":[{"award-number":["MCCOY19RO"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P30-DK125013"],"award-info":[{"award-number":["P30-DK125013"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:p>New research reveals that epithelial sodium channel (ENaC) overexpression in cystic fibrosis (CF) immune cells impairs macrophage function. Inhibiting ENaC increases cystic fibrosis transmembrane conductance regulator (CFTR) expression, normalizes reactive oxygen species production, improves autophagy, and reduces proinflammatory cytokine production. This suggests that ENaC modulation could be a novel therapeutic target for CF infection control, either alone or with CFTR modulators, offering new hope for patients not eligible for current treatments.<\/jats:p>","DOI":"10.1152\/ajplung.00009.2025","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:09:46Z","timestamp":1748851786000},"page":"L61-L69","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["ENaC contributes to macrophage dysfunction in cystic fibrosis"],"prefix":"10.1152","volume":"329","author":[{"given":"John","family":"Moran","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Pugh","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4229-9124","authenticated-orcid":false,"given":"Nevian","family":"Brown","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Thomas","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"McCauley","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Cephas","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra L.","family":"Shrestha","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-9440","authenticated-orcid":false,"given":"Santiago","family":"Partida-Sanchez","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Bai","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-4057","authenticated-orcid":false,"given":"Emanuela","family":"Bruscia","sequence":"additional","affiliation":[{"name":"Yale School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-7990","authenticated-orcid":false,"given":"Benjamin T.","family":"Kopp","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35151-7"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01871"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03540-9"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4RU0620-245R"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02861-2021"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.09.007"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2018.1501361"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.7543698"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.029"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106695108"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00382.2017"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49248"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008886200"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.11.003"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00538-6"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.06.066"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.7.2920"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.08.021"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112212"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201612-2445OC"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502609"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096681"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186169"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.11.17660"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.11.005"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052530"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.116038"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15306"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0910513"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.060988-0"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2011.01716.x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66473-4"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00009.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T17:05:17Z","timestamp":1752599117000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00009.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7,1]]}},"alternative-id":["10.1152\/ajplung.00009.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00009.2025","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.11.06.622340","asserted-by":"object"}]},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"2025-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}