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To investigate the link between COPD and atherosclerosis and to develop specific therapeutic strategies for COPD patients with atherosclerosis, a substantial number of preclinical studies using murine models have been performed. In this review, we summarize the currently used murine models of COPD and atherosclerosis, both individually and combined, and discuss the relevance of these models for studying the pathogenesis and development of new treatments for COPD patients with atherosclerosis. Murine and clinical studies have provided complementary information showing a prominent role for systemic inflammation and oxidative stress in the link between COPD and atherosclerosis. These and other studies showed that murine models for COPD and atherosclerosis are useful tools and can provide important insights relevant to understanding the link between COPD and CVD. More importantly, murine studies provide good platforms for studying the potential of promising (new) therapeutic strategies for COPD patients with CVD.<\/jats:p>","DOI":"10.1152\/ajplung.00013.2016","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T02:19:35Z","timestamp":1458353975000},"page":"L1011-L1027","source":"Crossref","is-referenced-by-count":11,"title":["Murine models of cardiovascular comorbidity in chronic obstructive pulmonary disease"],"prefix":"10.1152","volume":"310","author":[{"given":"P. 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