{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:28:14Z","timestamp":1790393294969,"version":"4.1.0"},"reference-count":69,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930031"],"award-info":[{"award-number":["81930031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971176"],"award-info":[{"award-number":["81971176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010882","name":"Tianjin Municipal Education Commission","doi-asserted-by":"publisher","award":["2019YJSS183"],"award-info":[{"award-number":["2019YJSS183"]}],"id":[{"id":"10.13039\/501100010882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:p> Acute lung injury (ALI), a common complication after traumatic brain injury (TBI), can evolve into acute respiratory distress syndrome (ARDS) and has a mortality rate of 30%\u201340%. Secondary ALI after TBI exhibits the following typical pathological features: infiltration of neutrophils into the alveolar and interstitial space, alveolar septal thickening, alveolar edema, and hemorrhage. Extracellular vesicles (EVs) were recently identified as key mediators in TBI-induced ALI. Due to their small size and lipid bilayer, they can pass through the disrupted blood-brain barrier (BBB) into the peripheral circulation and deliver their contents, such as genetic material and proteins, to target cells through processes such as fusion, receptor-mediated interactions, and uptake. Acting as messengers, EVs contribute to mediating brain-lung cross talk after TBI. In this review, we aim to summarize the mechanism of EVs in TBI-induced ALI, which may provide new ideas for clinical treatment. <\/jats:p>","DOI":"10.1152\/ajplung.00023.2021","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T12:00:31Z","timestamp":1632312031000},"page":"L885-L891","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["The role of extracellular vesicles in traumatic brain injury-induced acute lung injury"],"prefix":"10.1152","volume":"321","author":[{"given":"Chao-Nan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Long","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8218-6395","authenticated-orcid":true,"given":"Jian-Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/msj.20100"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30371-X"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.113080"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/00075198-200502000-00006"},{"key":"B5","first-page":"356","volume":"37","author":"Zhu L","year":"2007","journal-title":"Ann Clin Lab Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24908"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/cc12815"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1080\/02699050010013932"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3060"},{"key":"B10","first-page":"84","volume":"32","author":"Fulton RL","year":"1975","journal-title":"Rev Surg"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199704000-00009"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1773CP"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.06.62"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311170"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-598805"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-688838"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00429.2015"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5430"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/cells8010069"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1967.tb08741.x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.98"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-101512-122326"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.200956"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.068833"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.226456"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.06.001"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(01)00229-1"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0472TR"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.04.013"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5972152"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309846"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00354.2011"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-010-0239-3"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31816493ad"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017758"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000261"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0393OC"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-007-1475-8"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1385\/NCC:1:4:479"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2348"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-784108"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.02.028"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.214932"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-841932"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181b2b0f4"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s11373-006-9107-5"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.1995.0025"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9426-x"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-228551"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070069"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145607"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-208032"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0213-5"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81134"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1095"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2017_59"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.45"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-114637"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22497"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(12)70012-9"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/nature10759"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2396-6"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.007"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010259"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2014.00014"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040831"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051082"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00745-2017"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccx.0000155356.86241.c0"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00023.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T21:18:24Z","timestamp":1635974304000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00023.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,1]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,11,1]]}},"alternative-id":["10.1152\/ajplung.00023.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00023.2021","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,1]]},"assertion":[{"value":"2021-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}