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Recurrent respiratory infections are a common and challenging comorbidity, often leading to the development of bronchiectasis in individuals with A-T. The role of ATM in development of immune memory in response to recurrent respiratory viral infections is not well understood. Here, we infect wild-type (WT) and Atm-null mice with influenza A virus (IAV; HKx31, H3N2) and interrogate the immune memory with secondary infections designed to challenge the B cell memory response with homologous infection (HKx31) and the T cell memory response with heterologous infection (PR8, H1N1). Although Atm-null mice survived primary and secondary infections, they lost more weight than WT mice during secondary infections. This enhanced morbidity to secondary infections was not attributed to failure to effectively clear virus during the primary IAV infection. Instead, Atm-null mice developed persistent peribronchial inflammation, characterized in part by clusters of B220<jats:sup>+<\/jats:sup>B cells. Additionally, levels of select serum antibodies to hemagglutinin-specific IAV were significantly lower in Atm-null than WT mice. These findings reveal that Atm is required to mount a proper memory response to a primary IAV infection, implying that vaccination of children with A-T by itself may not be sufficiently protective against respiratory viral infections.<\/jats:p>","DOI":"10.1152\/ajplung.00031.2019","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T18:18:24Z","timestamp":1568225904000},"page":"L591-L601","source":"Crossref","is-referenced-by-count":6,"title":["Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection"],"prefix":"10.1152","volume":"317","author":[{"given":"Rachel","family":"Warren","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, New 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