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AKI associated with respiratory complications, in particular, has a poor outcome. In murine models, AKI is characterized by increased circulating cytokines, lung chemokine upregulation, and neutrophilic infiltration, similar to other causes of indirect acute lung injury (ALI; e.g., sepsis). Many causes of lung inflammation are associated with a lung metabolic profile characterized by increased oxidative stress, a shift toward the use of other forms of energy production, and\/or a depleted energy state. To our knowledge, there are no studies that have evaluated pulmonary energy production and metabolism after AKI. We hypothesized that based on the parallels between inflammatory acute lung injury and AKI-mediated lung injury, a similar metabolic profile would be observed. Lung metabolomics and ATP levels were assessed 4\u2009h, 24\u2009h, and 7\u2009days after ischemic AKI in mice. Numerous novel findings regarding the effect of AKI on the lung were observed including 1) increased oxidative stress, 2) a shift toward alternate methods of energy production, and 3) depleted levels of ATP. The findings in this report bring to light novel characteristics of AKI-mediated lung injury and provide new leads into the mechanisms by which AKI in patients predisposes to pulmonary complications.<\/jats:p>","DOI":"10.1152\/ajplung.00042.2020","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T08:11:03Z","timestamp":1620202263000},"page":"L50-L64","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion"],"prefix":"10.1152","volume":"321","author":[{"given":"Sophia L.","family":"Ambruso","sequence":"first","affiliation":[{"name":"Rocky Mountain Regional VA Medical Center, Denver, Colorado"},{"name":"University of Colorado Anschutz Medical Campus, Denver, 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