{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:46:57Z","timestamp":1787017617978,"version":"build-2736575974"},"reference-count":86,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R13HL170688"],"award-info":[{"award-number":["R13HL170688"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2327935"],"award-info":[{"award-number":["2327935"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>Repair and regeneration of a diseased lung using stem cells or bioengineered tissues is an exciting therapeutic approach for a variety of lung diseases and critical illnesses. Over the past decade, increasing evidence from preclinical models suggests that mesenchymal stromal cells, which are not normally resident in the lung, can be used to modulate immune responses after injury, but there have been challenges in translating these promising findings to the clinic. In parallel, there has been a surge in bioengineering studies investigating the use of artificial and acellular lung matrices as scaffolds for three-dimensional lung or airway regeneration, with some recent attempts of transplantation in large animal models. The combination of these studies with those involving stem cells, induced pluripotent stem cell derivatives, and\/or cell therapies is a promising and rapidly developing research area. These studies have been further paralleled by significant increases in our understanding of the molecular and cellular events by which endogenous lung stem and\/or progenitor cells arise during lung development and participate in normal and pathological remodeling after lung injury. For the 2023 Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases Conference, scientific symposia were chosen to reflect the most cutting-edge advances in these fields. Sessions focused on the integration of \u201comics\u201d technologies with function, the influence of immune cells on regeneration, and the role of the extracellular matrix in regeneration. The necessity for basic science studies to enhance fundamental understanding of lung regeneration and to design innovative translational studies was reinforced throughout the conference.<\/jats:p>","DOI":"10.1152\/ajplung.00052.2024","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T22:36:16Z","timestamp":1716330976000},"page":"L327-L340","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-8791","authenticated-orcid":false,"given":"Robert E.","family":"Hynds","sequence":"first","affiliation":[{"name":"Epithelial Cell Biology in ENT Research Group, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6988-8584","authenticated-orcid":false,"given":"Chelsea M.","family":"Magin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States"},{"name":"Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States"},{"name":"Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-6713","authenticated-orcid":false,"given":"Laertis","family":"Ikonomou","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, New York, United States"},{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8246-1083","authenticated-orcid":false,"given":"Yael","family":"Aschner","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2149-3209","authenticated-orcid":false,"given":"Michael F.","family":"Beers","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division, Department of Medicine and PENN-CHOP Lung Biology Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-9966","authenticated-orcid":false,"given":"Janette K.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6602-6700","authenticated-orcid":false,"given":"Rebecca L.","family":"Heise","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-7375","authenticated-orcid":false,"given":"Patrick S.","family":"Hume","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2380-5069","authenticated-orcid":false,"given":"Anna D.","family":"Krasnodembskaya","sequence":"additional","affiliation":[{"name":"Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen\u2019s University Belfast, Belfast, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4727-1177","authenticated-orcid":false,"given":"Shirley H. J","family":"Mei","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Misharin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-9287","authenticated-orcid":false,"given":"Jin-Ah","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-9025","authenticated-orcid":false,"given":"Daniel J.","family":"Tschumperlin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia E.","family":"Tanneberger","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Vaidyanathan","sequence":"additional","affiliation":[{"name":"Center for Gene Therapy, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6706-1284","authenticated-orcid":false,"given":"Christopher M.","family":"Waters","sequence":"additional","affiliation":[{"name":"Department of Physiology and Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J.","family":"Zettler","sequence":"additional","affiliation":[{"name":"Moritz College of Law, Drug Enforcement and Policy Center, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Vermont, Burlington, Vermont, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1363-905X","authenticated-orcid":false,"given":"Amy L.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00113.2022"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0286ST"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00123-2020"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201304-090AW"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1513\/pats.201012-071DW"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200804-037DW"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201606-466ST"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201502-086ST"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2020.04.001"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9750"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.959335"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202202992"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102154"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104730"},{"key":"B15","doi-asserted-by":"publisher","unstructured":"Koc-Gunel S, Gautam LK, Calvert BA, Murthy S, Harriott NC, Nawroth JC, Zhou B, Krymskaya VP, Ryan AL. Sorafenib inhibits invasion of multicellular organoids that mimic lymphangioleiomyomatosis nodules (Preprint).\n                      bioRxiv\n                      , 2023. doi:10.1101\/2023.06.12.544372. 37398026","DOI":"10.1101\/2023.06.12.544372"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163402"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95823"},{"key":"B18","doi-asserted-by":"publisher","unstructured":"Ma X, Shedlock CJ, Medina T, Ribas RA, Clarke HA, Hawkinson TR, Dande PK, Wu L, Burke SN, Merritt ME, Vander Kooi CW, Gentry MS, Yadav NN, Chen L, Sun RC. MetaVision3D: automated framework for the generation of spatial metabolome atlas in 3D (Preprint).\n                      bioRxiv\n                      , 2023. doi:10.1101\/2023.11.27.568931.38077043","DOI":"10.1101\/2023.11.27.568931"},{"key":"B19","doi-asserted-by":"publisher","unstructured":"Clarke HA, Ma X, Shedlock CJ, Medina T, Hawkinson TR, Wu L, Ribas RA, Keohane S, Ravi S, Bizon J, Burke S, Abisambra JF, Merritt M, Prentice B, Vander Kooi CW, Gentry MS, Chen L, Sun RC. Spatial metabolome lipidome and glycome from a single brain section (Preprint).\n                      bioRxiv\n                      , 2023. doi:10.1101\/2023.07.22.550155. 37546843","DOI":"10.1101\/2023.07.22.550155"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2030-4_15"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38437-1"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2410OC"},{"key":"B23","doi-asserted-by":"publisher","unstructured":"Bailey JI, Puritz CH, Senkow KJ, Markov NS, Diaz E, Jonasson E , et al Expansion of profibrotic monocyte-derived alveolar macrophages in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19 (Preprint).\n                      bioRxiv\n                      , 2023. doi:10.1101\/2023.07.30.551145.","DOI":"10.1101\/2023.07.30.551145"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac775"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-023-00295-2"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.33"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124958"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02595-3"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009619"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00092.2014"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2882-8"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202201458"},{"key":"B33","doi-asserted-by":"publisher","unstructured":"Li X, Mara AB, Musial S, Rawat K, King WT, Kolling FW, Gerebtsov N, Jakubzick CV. Coordinated chemokine expression defines macrophage subsets across tissues (Preprint).\n                      bioRxiv\n                      , 2023. doi:10.1101\/2023.05.12.540435.","DOI":"10.1101\/2023.05.12.540435"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201911-2105OC"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00074"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1177\/20417314211017417"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivx442"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26611"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00540"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.585625"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22907"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.03.023"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.11.002"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.01.019"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.05.013"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3791\/61929"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0274MA"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1414OC"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15581"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.06.019"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.01.059"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1242\/bio.059423"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201812-890CME"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2023.02.004"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.03.008"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.04.006"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.06.020"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0037MA"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123637"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201909-1726LE"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2021.11.014"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0095OC"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.152404"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-214986"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17358-3"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0542-8"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00809-4"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2023-0176PS"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1242\/bio.059436"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a039685"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112982"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01734-8"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071176"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.148983"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1349199"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26834-3"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.05.004"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1149"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.312"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201810-1855OC"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.04361-2020"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.030114"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0379OC"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204765"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.832178"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-009-0052-z"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00052.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T11:59:32Z","timestamp":1725364772000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00052.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":86,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9,1]]}},"alternative-id":["10.1152\/ajplung.00052.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00052.2024","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,1]]},"assertion":[{"value":"2024-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}