{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:12:14Z","timestamp":1794003134961,"version":"4.8.0"},"reference-count":34,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100003284","name":"Pulmonary Fibrosis Foundation (PFF)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003284","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:p>\n                    Fibroblast activation protein (FAP), a cell surface serine protease, is upregulated on a subset of activated fibroblasts (often distinct from \u03b1-smooth muscle actin-expressing myofibroblasts) associated with matrix remodeling, including fibroblasts in idiopathic pulmonary fibrosis (Acharya PS, Zukas A, Chandan V, Katzenstein AL, Pur\u00e9 E. Hum Pathol 37: 352\u2013360, 2006.). As FAP\n                    <jats:sup>+<\/jats:sup>\n                    fibroblasts could be pivotal in either breakdown and\/or production of collagen and other matrix components, the goal of this study was to define the role of FAP\n                    <jats:sup>+<\/jats:sup>\n                    cells in pulmonary fibrosis in two established, but different, mouse models of chronic lung fibrosis: repetitive doses of intratracheal bleomycin and a single dose of an adenoviral vector encoding constitutively active TGF-\u03b21 (Ad-TGF\u03b2). To determine their role in fibrotic remodeling, FAP-expressing cells were depleted by injection of T cells expressing a chimeric antigen receptor specific for murine FAP in mice with established fibrosis. The contribution of FAP to the function of FAP-expressing cells was assessed in FAP knockout mice. Using histological analyses, quantification of soluble collagen content, and flow cytometry, we found that loss of FAP\n                    <jats:sup>+<\/jats:sup>\n                    cells exacerbated fibrosis in the bleomycin model, a phenotype largely recapitulated by the genetic deletion of FAP, indicating that FAP plays a role in this model. In contrast, depletion of FAP\n                    <jats:sup>+<\/jats:sup>\n                    cells or genetic deletion of FAP had little effect in the Ad-TGF\u03b2 model highlighting the potential for distinct mechanisms driving fibrosis depending on the initiating insult. The role of FAP in human lung fibrosis will need to be well understood to guide the use of FAP-targeted therapeutics that are being developed.\n                  <\/jats:p>","DOI":"10.1152\/ajplung.00071.2019","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T09:37:43Z","timestamp":1560332263000},"page":"L271-L282","source":"Crossref","is-referenced-by-count":45,"title":["Loss of cells expressing fibroblast activation protein has variable effects in models of TGF-\u03b2 and chronic bleomycin-induced fibrosis"],"prefix":"10.1152","volume":"317","author":[{"given":"Toru","family":"Kimura","sequence":"first","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Monslow","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Pennsylvania School of Veterinary 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