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Long non-coding RNAs (lncRNAs) are involved in various pathophysiological processes. In the present study, we investigated the effect of PM<jats:sub>2.5<\/jats:sub> on the epithelial-mesenchymal transition (EMT) in lung bronchial epithelial cells and the underlying mechanisms mediated by an lncRNA. Organic extracts of PM<jats:sub>2.5<\/jats:sub> from Shanghai were used to treat human bronchial epithelial cell lines (HBE and BEAS-2B). The PM<jats:sub>2.5<\/jats:sub> organic extracts induced the EMT and cell transformation. High levels of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), mediated by NF-\u03baB, were involved in the EMT process. For both cell lines, there was a similar response. In addition, MALAT1 interacted with miR-204 and reversed the inhibitory effect of its target gene, ZEB1, thereby contributing to the EMT and malignant transformation. In sum, these findings show that NF-\u03baB transcriptionally regulates MALAT1, which, by binding with miR-204 and releasing ZEB1, promotes the EMT. These results offer an understanding of the regulatory network of the PM<jats:sub>2.5<\/jats:sub>-induced EMT that relates to the health risks associated with PM<jats:sub>2.5<\/jats:sub>. <\/jats:p>","DOI":"10.1152\/ajplung.00073.2019","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T13:32:38Z","timestamp":1556717558000},"page":"L87-L98","source":"Crossref","is-referenced-by-count":37,"title":["LncRNA MALAT1, an lncRNA acting via the miR-204\/ZEB1 pathway, mediates the EMT induced by organic extract of PM<sub>2.5<\/sub> in lung bronchial epithelial cells"],"prefix":"10.1152","volume":"317","author":[{"given":"Fei","family":"Luo","sequence":"first","affiliation":[{"name":"Faculty of Public Health, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Wei","sequence":"additional","affiliation":[{"name":"The Ninth People\u2019s Hospital Affiliated to 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