{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:51:17Z","timestamp":1780793477316,"version":"3.54.1"},"reference-count":43,"publisher":"American Physiological Society","issue":"4","funder":[{"name":"HHS | NIH | NHLBI | NHLBI Division of Intramural Research","award":["T32-HL06698"],"award-info":[{"award-number":["T32-HL06698"]}]},{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30-ES001247"],"award-info":[{"award-number":["P30-ES001247"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["K08-ES033290"],"award-info":[{"award-number":["K08-ES033290"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p> Interleukin-17A (IL-17A) neutralization has shown benefit previously in preclinical models of transplant-associated bronchiolitis obliterans (BO), yet it remains unknown whether IL-17A neutralization has similar benefit for other forms of BO. Here, IL-17A neutralization fails to prevent severe airway remodeling in rats exposed repetitively to the flavoring chemical diacetyl, and instead, promotes a proinflammatory microenvironment with increased expression of TNF-\u03b1, IL-1\u03b2, and NF-\u03baB within the lung. <\/jats:p>","DOI":"10.1152\/ajplung.00082.2023","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T15:00:30Z","timestamp":1693321230000},"page":"L434-L446","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["IL-17A neutralization fails to attenuate airway remodeling and potentiates a proinflammatory lung microenvironment in diacetyl-exposed rats"],"prefix":"10.1152","volume":"325","author":[{"given":"Emma L.","family":"House","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Rochester Medical Center, Rochester, New York, United States"},{"name":"Department of Pediatrics, Division of Pediatric Pulmonology, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-9770","authenticated-orcid":false,"given":"So-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Pulmonology, University of Rochester Medical Center, Rochester, New York, United States"},{"name":"Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chalupa","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hernady","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States"},{"name":"Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1810-5532","authenticated-orcid":false,"given":"Angela M.","family":"Groves","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States"},{"name":"Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York, United States"},{"name":"Department of Pediatrics, Division of Neonatology, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States"},{"name":"Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York, United States"},{"name":"Department of Pediatrics, Division of Neonatology, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-3560","authenticated-orcid":false,"given":"Matthew D.","family":"McGraw","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Pulmonology, University of Rochester Medical Center, Rochester, New York, United States"},{"name":"Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2838"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3280298235"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/15459624.2016.1177649"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/0192623319879906"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000194152.48728.fb"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.561740"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2016.10.013"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn016"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311431946"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017644"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00107514"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15167"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2021.101467"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13215"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001917"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0257-9"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6309219"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0154OC"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002837"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070236"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-021-03076-2"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/toxics9120359"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03482.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.616309"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2144\/000112729"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32833b7929"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10123277"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1204664"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0168OC"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13595"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0253-0"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.022"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00163"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181e8dabe"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.147282"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1172\/jci159229"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4368"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112920"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004081"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01430.x"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1667\/rr14874.1"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1172\/jci12214"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0451OC"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00082.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T20:14:20Z","timestamp":1695327260000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00082.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10,1]]}},"alternative-id":["10.1152\/ajplung.00082.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00082.2023","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,1]]},"assertion":[{"value":"2023-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}