{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:20:39Z","timestamp":1789417239652,"version":"build-2803163510"},"reference-count":17,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>PDGF isoforms are a family of polypeptides that bind to cell surface receptors and induce fibroblast proliferation and chemotaxis. The PDGF-A and -B chain isoforms have been implicated in fibroproliferative lung injury in animal models and in human disease. Two recently recognized PDGF polypeptides, PDGF-C and -D, differ from the PDGF-A and -B isoforms in that they require proteolytic cleavage before they can bind and activate the PDGF receptors. Our findings demonstrate that administration of bleomycin to murine lungs leads to a significant increase in PDGF-C mRNA expression and a significant decrease in PDGF-D mRNA expression. PDGF-C expression was localized to areas of lung injury by in situ hybridization, and PDGF-C expression was not upregulated in the lungs of BALB\/c mice that are resistant to bleomycin-induced lung fibrosis. Moreover, there is in vivo phosphorylation of the PDGF-receptor that binds PDGF-C in response to bleomycin administration. These observations strongly suggest a role for PDGF-C in bleomycin-induced pulmonary fibrosis.<\/jats:p>","DOI":"10.1152\/ajplung.00083.2003","type":"journal-article","created":{"date-parts":[[2004,1,31]],"date-time":"2004-01-31T00:55:58Z","timestamp":1075510558000},"page":"L182-L188","source":"Crossref","is-referenced-by-count":57,"title":["Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis"],"prefix":"10.1152","volume":"286","author":[{"given":"Ying","family":"Zhuo","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Laboy","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Lasky","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114808"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.276.2.L311"},{"key":"REF3","doi-asserted-by":"crossref","unstructured":"Heldin CH, Ostman A, and Ronnstrand L.Signal transduction via platelet-derived growth factor receptors.Biochim Biophys Acta1378: F79-F113, 1998.","DOI":"10.1016\/S0304-419X(98)00015-8"},{"key":"REF4","doi-asserted-by":"crossref","unstructured":"Heldin CHand Westermark B.Signal transduction by the receptors for platelet-derived growth factor.Science96: 193-196, 1990.","DOI":"10.1242\/jcs.96.2.193"},{"key":"REF5","doi-asserted-by":"crossref","unstructured":"Jules-Elysee Kand White DA.Bleomycin-induced pulmonary toxicity.Clin Chest Med11: 1-20, 1990.","DOI":"10.1016\/S0272-5231(21)00668-7"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1038\/35074593"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s4751"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1080\/01902140290096755"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1038\/35010579"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.3.780"},{"key":"REF11","unstructured":"Raines E.Platelet-derived growth factor. In:Peptide Growth Factors and Their Receptors. Handbook of Experimental Pharmacology, edited by Sporn MB and Roberts AB. Berlin: Springer, 1990, p. 419-472."},{"key":"REF12","unstructured":"Song M, He B, and Qiu Z.Expressions of TNF alpha, PDGF in alveolar type II epithelial cells of rats with bleomycin-induced pulmonary fibrosis.Zhonghua Jie He He Hu Xi Za Zhi21: 221-223, 1998."},{"key":"REF13","unstructured":"Umezawa H.Bleomycin and other antitumor antibiotics of high molecular weight.Antimicrobial Agents Chemother5: 1079-1085, 1965."},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.18.2242"},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/9.6.637"},{"key":"REF16","doi-asserted-by":"crossref","unstructured":"Yoshida M, Sakuma-Mochizuki J, Abe K, Arai T, Mori M, Goya S, Matsuoka H, Hayashi S, Kaneda Y, and Kishimoto T.In vivo gene transfer of an extracellular domain of platelet-derived growth factor beta receptor by the HVJ-liposome method ameliorates bleomycin-induced pulmonary fibrosis.Biochem Biophys Res Commun65: 503-508, 1999.","DOI":"10.1006\/bbrc.1999.1647"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01346-9"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajplung.00083.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T05:30:20Z","timestamp":1623648620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajplung.00083.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1152\/ajplung.00083.2003"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00083.2003","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}