{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:01:01Z","timestamp":1793055661049,"version":"4.5.0"},"reference-count":46,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100017540","name":"HHS | NIH | NHLBI | Division of Intramural Research","doi-asserted-by":"publisher","award":["R01 HL088029"],"award-info":[{"award-number":["R01 HL088029"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"HHS | NIH | NHLBI | Division of Intramural Research","doi-asserted-by":"publisher","award":["R01 HL142061"],"award-info":[{"award-number":["R01 HL142061"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:p> Our previous study suggests that glial-derived neurotrophic factor (GDNF) is involved in allergen-induced airway hyperreactivity and remodeling in vivo. Here, we show that GDNF has no direct effects in remodeling of human airway smooth muscle (ASM) but GDNF dysregulates mitochondrial morphology in human ASM in the context of asthma. <\/jats:p>","DOI":"10.1152\/ajplung.00101.2024","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T18:10:50Z","timestamp":1727201450000},"page":"L684-L693","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of glial-derived neurotrophic factor on remodeling and mitochondrial function in human airway smooth muscle cells"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-7647","authenticated-orcid":false,"given":"Li Y.","family":"Drake","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin B.","family":"Roos","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3361-5859","authenticated-orcid":false,"given":"Jacob J.","family":"Teske","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-8798","authenticated-orcid":false,"given":"Niyati A.","family":"Borkar","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita","family":"Ayyalasomayajula","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Klapperich","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-3983","authenticated-orcid":false,"given":"Maunick Lefin","family":"Koloko Ngassie","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-2174","authenticated-orcid":false,"given":"Christina M.","family":"Pabelick","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States"},{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2968-224X","authenticated-orcid":false,"given":"Y. S.","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States"},{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-020-03287-6"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-020-03262-1"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-020-03227-4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/381789a0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrn812"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.01.021"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0717-8_2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000921"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00786"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/s1359-6101(01)00012-0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040865"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.76"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30489"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00366.2011"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-6338"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00099.2023"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009367"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S280247"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0235TR"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-213738"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00396.2015"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-141"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0320OC"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070956"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/261297"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798764870"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1101\/gad.408407"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000441"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00259.2013"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00370.2016"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-3073"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1586\/ers.10.29"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2021.01.008"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk2758"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/ph4030429"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.03.020"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.010"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010305.104638"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219855"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2008"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12378"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303554"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713033"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201284290"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79300"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1036907"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00101.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T18:48:57Z","timestamp":1730314137000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00101.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,1]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11,1]]}},"alternative-id":["10.1152\/ajplung.00101.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00101.2024","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,1]]},"assertion":[{"value":"2024-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}