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Few studies have delineated the mechanisms by which maternal nutrition affects fetal lung development. Here, we report that maternal exposure to a diet high in fat (HFD) causes placental inflammation, resulting in placental insufficiency, fetal growth restriction (FGR), and inhibition of fetal lung development. Notably, pre- and postnatal exposure to maternal HFD also results in persistent alveolar simplification in the postnatal period. Our novel findings provide a strong association between maternal diet and fetal lung development.<\/jats:p>","DOI":"10.1152\/ajplung.00105.2015","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T02:40:35Z","timestamp":1434768035000},"page":"L360-L368","source":"Crossref","is-referenced-by-count":67,"title":["Maternal high-fat diet is associated with impaired fetal lung development"],"prefix":"10.1152","volume":"309","author":[{"given":"Reina S.","family":"Mayor","sequence":"first","affiliation":[{"name":"Center for Pulmonary and Vascular Biology and Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn E.","family":"Finch","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Zehr","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; 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