{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:20:28Z","timestamp":1777706428608,"version":"3.51.4"},"reference-count":29,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p> Asthma is a common chronic inflammatory disease involving many different cell types. Recently, type I natural killer T (NKT) cells have been demonstrated to play a crucial role in the development of asthma. However, the roles of type II NKT cells in asthma have not been investigated before. Interestingly, type I and type II NKT cells have been shown to have opposing roles in antitumor immunity, antiparasite immunity, and autoimmunity. We hypothesized that sulfatide-activated type II NKT cells could prevent allergic airway inflammation by inhibiting type I NKT cell function in asthma. Strikingly, in our mouse model, activation of type II NKT cells by sulfatide administration and adoptive transfer of sulfatide-activated type II NKT cells result in reduced-inflammation cell infiltration in the lung and bronchoalveolar lavage fluid, decreased levels of IL-4 and IL-5 in the BALF; and decreased serum levels of ovalbumin-specific IgE and IgG1. Furthermore, it is found that the activation of sulfatide-reactive type II NKT cells leads to the functional inactivation of type I NKT cells, including the proliferation and cytokine secretion. Our data reveal that type II NKT cells activated by glycolipids, such as sulfatide, may serve as a novel approach to treat allergic diseases and other disorders characterized by inappropriate type I NKT cell activation. <\/jats:p>","DOI":"10.1152\/ajplung.00114.2011","type":"journal-article","created":{"date-parts":[[2011,8,20]],"date-time":"2011-08-20T02:20:51Z","timestamp":1313806851000},"page":"L975-L984","source":"Crossref","is-referenced-by-count":38,"title":["Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma"],"prefix":"10.1152","volume":"301","author":[{"given":"Guqin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanxiang","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Renmin Hospital 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