{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:31:32Z","timestamp":1782977492875,"version":"3.54.5"},"reference-count":34,"publisher":"American Physiological Society","issue":"7","funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland (SFI)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:p>Pulmonary fibrosis is a progressive and fatal disease that involves the remodeling of the distal airspace and the lung parenchyma, which results in compromised gas exchange. The median survival time once diagnosed is less than three years. Interleukin (IL)-13 has been shown to play a role in a number of inflammatory and fibrotic diseases. IL-13 modulates its effector functions via a complex receptor system that includes the IL-4 receptor (R) \u03b1, IL-13R\u03b11, and the IL-13R\u03b12. IL-13R\u03b11 binds IL-13 with low affinity, yet, when it forms a complex with IL-4\u03b1, it binds with much higher affinity, inducing the effector functions of IL-13. IL-13R\u03b12 binds IL-13 with high affinity but has a short cytoplasmic tail and has been shown to act as a nonsignaling decoy receptor. Transfection of fibroblasts and epithelial cells with IL-13R\u03b12 inhibited the IL-13 induction of soluble collagen, TGF-\u03b2, and CCL17. Adenoviral overexpression of IL-13R\u03b12 in the lung reduced bleomycin-induced fibrosis. Our work shows that overexpression of IL-13R\u03b12 inhibits the IL-13 induction of fibrotic markers in vitro and inhibits bleomycin-induced pulmonary fibrosis. In summary our study highlights the antifibrotic nature of IL-13Ra2.<\/jats:p>","DOI":"10.1152\/ajplung.00120.2014","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T05:21:29Z","timestamp":1423286489000},"page":"L710-L718","source":"Crossref","is-referenced-by-count":41,"title":["Modulation of pulmonary fibrosis by IL-13R\u03b12"],"prefix":"10.1152","volume":"308","author":[{"given":"Robert V.","family":"Lumsden","sequence":"first","affiliation":[{"name":"Conway Institute of Biomedical and Biomolecular Science, University College Dublin, Dublin, Ireland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C.","family":"Worrell","sequence":"additional","affiliation":[{"name":"Conway Institute of Biomedical and Biomolecular Science, University College Dublin, Dublin, Ireland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Boylan","sequence":"additional","affiliation":[{"name":"Conway Institute of 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