{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T05:16:01Z","timestamp":1794201361021,"version":"4.8.0"},"reference-count":50,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["5UL1TR002243-03"],"award-info":[{"award-number":["5UL1TR002243-03"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL136888"],"award-info":[{"award-number":["HL136888"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL160551"],"award-info":[{"award-number":["HL160551"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL126671"],"award-info":[{"award-number":["HL126671"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL150783"],"award-info":[{"award-number":["HL150783"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL158906"],"award-info":[{"award-number":["HL158906"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL164937"],"award-info":[{"award-number":["HL164937"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM141927"],"award-info":[{"award-number":["GM141927"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-18-1-0683"],"award-info":[{"award-number":["W81XWH-18-1-0683"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX002288"],"award-info":[{"award-number":["I01BX002288"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:p> Cell-free hemoglobin (CFH) is elevated in the airspace of most patients with acute respiratory distress syndrome and causes severe inflammation. Here, we identify that CFH contributes to macrophage-induced cytokine production via Toll-like receptor 4 (TLR4) and myeloid differentiation primary response 88 (MyD88) signaling. These data increase our knowledge of the mechanisms through which CFH contributes to lung injury and may inform development of targeted therapeutics to attenuate inflammation. <\/jats:p>","DOI":"10.1152\/ajplung.00123.2023","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T15:51:14Z","timestamp":1700668274000},"page":"L29-L38","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Cell-free hemoglobin triggers macrophage cytokine production via TLR4 and MyD88"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8473-6642","authenticated-orcid":false,"given":"Kaitlyn R.","family":"Schaaf","sequence":"first","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"},{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart R.","family":"Landstreet","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangami","family":"Pugazenthi","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Y.","family":"Qian","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan D.","family":"Putz","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Siderova","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5623-4891","authenticated-orcid":false,"given":"Allison M.","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K.","family":"Bohannon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States"},{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9429-4702","authenticated-orcid":false,"given":"Lorraine B.","family":"Ware","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"},{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0458-6507","authenticated-orcid":false,"given":"Julie A.","family":"Bastarache","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"},{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States"},{"name":"Department of Cell and Molecular Biology, Vanderbilt University, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-0288","authenticated-orcid":false,"given":"Ciara M.","family":"Shaver","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0069-0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2014.08.004"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-201781"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00155.2015"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14589"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00461"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.010090"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.01.006"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4161\/cib.29053"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.14670\/HH-21.687"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.788-794.2004"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-5-1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.043"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00415.2010"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00412.2003"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2158-y"},{"key":"B17","first-page":"2563","volume":"197","author":"Hoshino K","year":"1999","journal-title":"J Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00069.2012"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2741\/4176"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.09.019"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01667"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00066.2013"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-495887"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2085"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008942828960"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.05.053"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.016"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nature01889"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000050284.35609.97"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/srep22249"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0179OC"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3791\/50072"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.068064"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047333"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103623"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00311"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16035028"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M610737200"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-375303"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-016-0955-9"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64578"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-46"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00211.2022"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814797116"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2013.05.004"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.08.005"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1159\/000519200"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29976"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02264-7"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00123.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T20:34:31Z","timestamp":1704314071000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00123.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,1]]}},"alternative-id":["10.1152\/ajplung.00123.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00123.2023","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,1]]},"assertion":[{"value":"2023-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}