{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:45:59Z","timestamp":1776973559701,"version":"3.51.4"},"reference-count":44,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>COPD-derived AECs exhibit higher susceptibility to CSE-induced HOTAIR upregulation. CSE induces distinct histone modification patterns (H3K4me3) specifically in COPD-derived AECs. HOTAIR is essential for mediating CSE-induced proinflammatory responses in AECs.<\/jats:p>","DOI":"10.1152\/ajplung.00126.2025","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:00:53Z","timestamp":1772643653000},"page":"L446-L456","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["LncRNA HOTAIR contributes to cigarette smoke-induced pro-inflammatory responses in human airway epithelial cells"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-8752","authenticated-orcid":false,"given":"Xinzi","family":"Zheng","sequence":"first","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["The Netherlands"]},{"name":"University of Groningen, University Medical Center Groningen","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-1773","authenticated-orcid":false,"given":"Priscila P.","family":"Villegas","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["The Netherlands"]},{"name":"University of Groningen, University Medical Center Groningen","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-6521","authenticated-orcid":false,"given":"Martijn C.","family":"Nawijn","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["The Netherlands"]},{"name":"University of Groningen, University Medical Center Groningen","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-8932","authenticated-orcid":false,"given":"Irene H.","family":"Heijink","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["The Netherlands"]},{"name":"University of Groningen, University Medical Center Groningen","place":["The Netherlands"]},{"name":"University of Groningen, University Medical Center Groningen","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00128008"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092145"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00512"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0200TR"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0342-2"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1021\/pr400998n"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041892"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.18.6891-6903.2000"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-291x(02)03029-2"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0184TR"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S354634"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.022"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03612-x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-014-0090-4"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051197"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2015.07.001"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00254-x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31998-7"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2019.05.009"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02234-z"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36130"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2174\/138945006777435263"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.36740\/merkur202304103"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-1982LE"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.21"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216445"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00252.2021"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203520"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-023-01430-y"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02852-4"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000002131"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021898"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.015"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00303503"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.4.9802078"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.7.583"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.18411.1"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-20-760"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.220"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.7150\/jca.27098"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25349"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s13665-013-0052-2"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00581-2023"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02153-z"}],"container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajplung.00126.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:30:15Z","timestamp":1776972615000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajplung.00126.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"alternative-id":["10.1152\/ajplung.00126.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajplung.00126.2025","relation":{},"ISSN":["1040-0605","1522-1504"],"issn-type":[{"value":"1040-0605","type":"print"},{"value":"1522-1504","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}