{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:34:08Z","timestamp":1792056848473,"version":"4.4.0"},"reference-count":56,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Lung Cellular and Molecular Physiology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>Interleukin-12 (IL-12), a Th1 proinflammatory cytokine, is reported to be increased in Sj\u00f6gren syndrome. To evaluate the effects of local Th1\/Th2 deregulation, we generated a transgenic mouse model that overexpresses IL-12 in the lungs. IL-12 transgenic mice developed bronchial and alveolar abnormalities strikingly similar to those found in the lungs of Sj\u00f6gren patients. Pathologically, lung abnormalities began at \u223c4 mo of age and were characterized by lymphocytic infiltrates around the bronchi, intraluminal periodic acid Schiff-positive debris, increased cell proliferation in the alveolar region, and increased interstitial and alveolar macrophages. Functionally, these abnormalities translated into decreased mucociliary clearance ( P &lt; 0.05 vs. wild-type littermates) and increased oxidative stress ( P &lt; 0.01). The pathological and functional abnormalities were accompanied by significant changes in lung natural killer (NK) cells. The number of NK cells was fourfold higher in IL-12 transgenic than wild-type lungs (20% of all lymphoid cells vs. 5%) during the first month of life. NK cells then decreased within a narrow window of time (from 30 to 50 days of age), reaching a nadir of \u223c2% on day 50, and remained at these low levels thereafter. This new mouse model highlights the role of IL-12 in the initiation of Sj\u00f6gren syndrome.<\/jats:p>","DOI":"10.1152\/ajplung.00134.2006","type":"journal-article","created":{"date-parts":[[2006,6,2]],"date-time":"2006-06-02T20:37:27Z","timestamp":1149280647000},"page":"L837-L846","source":"Crossref","is-referenced-by-count":35,"title":["IL-12 overexpression in mice as a model for Sj\u00f6gren lung disease"],"prefix":"10.1152","volume":"291","author":[{"given":"Sharon","family":"McGrath-Morrow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Laube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shey-Cherng","family":"Tzou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Cleary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel R.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Caturegli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1089\/0894268041457138"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.03.006"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.1.399"},{"key":"R4","unstructured":"Battista G\n                      , Zompatori M, Poletti V, and Canini R.\n                      Thoracic manifestations of the less common collagen diseases. A pictorial essay.\n                      Radiol Med (Torino)\n                      106\n                      : 445\u2013453, 2003."},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.034900"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2003.11.007"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2005.02.004"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(99)00250-6"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1995.1128"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3049"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.2.226"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Constantopoulos SH\n                      , Tsianos EV, and Moutsopoulos HM.\n                      Pulmonary and gastrointestinal manifestations of Sjogren's syndrome.\n                      Rheum Dis Clin North Am\n                      18\n            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